| Project/Area Number |
25750201
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nagoya University |
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Principal Investigator |
LEE Sachiko 名古屋大学, 医学(系)研究科(研究院), 助教 (80599316)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | spasticity / stroke / KCC2 / Ia afferent fibers / 痙縮 / 脳梗塞 / リハビリテーション |
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| Outline of Final Research Achievements |
An estimated 42.6%of post-stroke patients exhibit spasticity 6 months post-stroke, and this disrupts their ability to perform activities of daily living and decrease their quality of life. In this study, we uncovered that significant reduction of KCC2 (potassium-chloride cotransporter 2) at 7 d post-stroke and phosphorylation of KCC2 serine residue 940 (S940) at 3 and 7 d post-stroke in motoneuron plasma membranes, since this is the main chloride extruder that affects neuronal excitability. In addition, at 7 and 42 d post-stroke, experimental mice exhibited a significant increase in vGluT1 (vesicular glutamate transporter 1)- positive boutons (almost Ia afferent fibers)compared with sham mice. Our findings suggest that both the down-regulation of KCC2 and increases in La afferent fibers are involved in post-stroke spasticity.
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