Oxidative stress markers for rehabilitation on patients with mechanical ventilation

• Project/Area Number: 25750204
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Hiroshima University
• Principal Investigator: Taito Shunsuke 広島大学, 病院(医), 理学療法士 (50613501)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 人工呼吸患者 / 酸化ストレス / リハビリテーション / 離床 / 人工呼吸器装着患者 / 喫煙 / 運動

Outline of Final Research Achievements

We examined pulmonary oxidative stress in cigarette smokers and non-smokers as preliminary study in order to clarify the effect of rehabilitation on pulmonary oxidative stress in patients with mechanical ventilation. We chose hydrogen peroxide concentrations in exhaled breath condensate as oxidative stress markers. The study suggested that moderate-intensity exercise did not induce pulmonary oxidative stress in cigarette smokers. We examined the change of hydrogen peroxide concentrations in exhaled breath condensate after rehabilitation in patients with mechanical ventilation. The results suggested that rehabilitation induced pulmonary oxidative stress in patients with mechanical ventilation.

Research Products

• [Journal Article] Oxidative stress in cigarette smokers and patients with chronic obstructive pulmonary disease (2017)
  • Author(s): Taito S, Hamada H, Sekikawa K, Kamikawa N, Takahashi M.
  • Journal Title: Oxid Antioxid Med Sci Volume: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Oxidative stress induced by smoking and exercise (2016)
  • Author(s): Taito S., Hamada H., Sekikawa K., Kamikawa N., Takahashi M., Kimura T.
  • Journal Title: Int J Med Biol Front Volume: 22
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cigarette Smoking does not Induce Plasma or Pulmonary Oxidative Stress after Moderate-intensity Exercise (2014)
  • Author(s): Shunsuke Taito, Sayaka Domen, Kiyokazu Sekikawa, Norimichi Kamikawa, Keisuke Oura, Tatsushi Kimura, Makoto Takahashi, Hironobu Hamada
  • Journal Title: Journal of Physical Therapy Science Volume: 26 Issue: 3 Pages: 413-415
  • DOI: 10.1589/jpts.26.413
  • NAID: 130004834979
  • ISSN: 0915-5287, 2187-5626
  • Peer Reviewed
• [Presentation] Pulmonary oxidative stress is induced by smoking in young cigarette smokers (2014)
  • Author(s): Taito S., Sekikawa K., Takahashi M., Kimura T., Hamada H.
  • Organizer: European Respiratory Society Annual Congress Munich 2014
  • Place of Presentation: Munich, Germany
  • Year and Date: 2014-09-06 – 2014-09-10
• [Book] Reactive Oxygen Species (ROS): Formation Mechanisms, Physiological Roles and Common Harmful Effects (2013)
  • Author(s): Lenaz G, Kolupaec Y, Karpets V, Shah D, Wu M, Lipovsky A, Perelstein I, Perkas N, lunbart R, Gedanken A, Khanna D, Garg M, Ochiai T, Gonzalez-Burgos E, Gomez-Serranillos M, Zhang M, Xue Y, Li Y, Han F, Xu W, Shi Z, Chen J, Shibaguchi H, Taito S, Hamada H, Kurusu T, Huseynova IM, Martinotti S, Podaza El.
  • Total Pages: 377
  • Publisher: NOVA Science Publishers