Skilled motor training increases synaptic delivery of AMPA receptors at layers II/III synapses in primary motor cortex
| Project/Area Number |
25750206
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Yamaguchi University |
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Principal Investigator |
KIDA Hiroyuki 山口大学, 大学院医学系研究科, 助教 (70432739)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | シナプス可塑性 / 運動学習 / 一次運動野 / AMPA受容体 / グルタミン酸 |
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| Outline of Final Research Achievements |
Synaptic plasticity mediated by AMPA glutamate receptors is highly associated with many types of learning. To analyze plasticity in layers II/III area in primary motor cortex, we subjected rats to a rotor rod test. Motor skill consistently improved within 2 days of training, and we prepared acute brain slices for patch clamp analyses.1-day trained rats exhibited significantly higher AMPA/NMDA ratios and miniature EPSC amplitude than untrained rats, suggesting an increase in postsynaptic AMPA receptors in the early phase of motor learning. Animals trained for 2 days showed a significantly higher miniature EPSC amplitude and frequency than untrained rats. Paired-pulse analysis of evoked EPSC significantly decreased after 2-days training, suggesting increased presynaptic glutamate release at the late phase of learning. Here we revealed that motor training induces dynamic changes in glutamatergic plasticity in layers II/III neurons of the primary motor cortex.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] The effect of hypothermia therapy in neonatal mice on the cortical laminar disruption following ischemic injury in neonatal mice.2013
Author(s)
Kida, H., Nomura, S., Shinoyama, M., Ideguchi, M., Owada, Y. and Suzuki, M.
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Journal Title
PLos One
Volume: 8
Issue: 7
Pages: e68877-e68877
DOI
Related Report
Peer Reviewed
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[Journal Article] Penicillin-induced epileptiform activity elevates focal brain temperature in anesthetized rats.2013
Author(s)
Tokiwa T, Inoue T, Fujii M, Ishizuka S, Aou S, Kida H, Maruta Y, Yamakawa T, Nomura S, Suzuki M, Yamakawa T.
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Journal Title
Neurosci Res.
Volume: 76
Issue: 4
Pages: 257-260
DOI
Related Report
Peer Reviewed
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