| Project/Area Number |
25750231
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Niigata University of Health and Welfare (2014-2015)
Nagoya Gakuin University (2013) |
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Principal Investigator |
tamakoshi keigo 新潟医療福祉大学, 医療技術学部, 助教 (30632658)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 脳出血 / スキルトレーニング / 神経可塑性 / 脳出血モデルラット / AMPA受容体 |
|---|
| Outline of Final Research Achievements |
In this study, we examined the effects of motor skills training on the sensorimotor function and synaptic plasticity after intracerebral hemorrhage in rats. We analyzed sensorimotor funtion, deltaFosB positive neuron, PSD95 protein expression, the mRNA expression of MAP2, GAP43, BDNF and AMPA in rat with motor skills training or no exercise. Our results demonstrated that sensorimotor functional recovery following motor skills training after ICH is promoted by neural plasticity related protein and mRNA expression in the sensorimotor cortex.
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