Fundamental research for constructing a new physical therapy strategy for widesprear chronic pain after physical immobilizaiton
| Project/Area Number |
25750237
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Rehabilitation science/Welfare engineering
|
|---|
| Research Institution | Aichi Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 不動化 / ミクログリア / アストロサイト / 酸化ストレス / 神経原性炎症 / 不快情動 / 慢性痛 / 不活動 / 運動器 / グリア / リン酸化 / 神経性炎症 / グリア細胞 / 活性酸素 / ギプス固定 |
|---|
| Outline of Final Research Achievements |
In order to construct a new physiotherapy strategy for widespread chronic pain after physical immobilization, we analyzed pathophysiological mechanism using our chronic post-cast pain (CPCP) model. We found that oxidative damage, caused by two weeks cast immobilization, occurred in a wide area (muscle, muscle spindle and the like) of the immobilized hind limb. Also, our findings suggested the following: ①the oxidative damage induced hyper excitability of nociceptive neurons and neurogenic inflammation in the immobile limb; ②the neuropeptide signal generated by this neurogenic inflammation causes hyper-excitation of spinal dorsal horn neurons and causes central sensitization; ③ the behavior of mechanical hyperalgesia in the chronic phase is secondary to oxidative impairment in immobile limb.
|
Report
(5 results)
Research Products
(15 results)
-
[Journal Article] Integration of a Kampo medicine, Nijutsuto, and Western medical treatment in the treatment of long-term frozen shoulder refractory to Western medical treatment: a case series.2015
Author(s)
Arai YC, Shimo K, Inoue M, Sakurai H, Ohmichi Y, Matsubara T, Nishihara M, Kawai T, Ikemoto T, Inoue S.
-
Journal Title
J Evid Based Complementary Altern Med.
Volume: 20
Issue: 2
Pages: 157-60
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] The efficacy of a multidisciplinary group program for patients with refractory chronic pain.2014
Author(s)
Inoue M, Inoue S, Ikemoto T, Arai YC, Nakata M, Miyazaki A, Nishihara M, Kawai T, Hatakeyama N, Yamaguchi S, Shimo K, Miyagawa H, Hasegawa T, Sakurai H, Hasegawa Y, Ohmichi Y, Ushida T.
-
Journal Title
Pain Res Manag.
Volume: 19
Pages: 302-8
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
