| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
In order to construct a new physiotherapy strategy for widespread chronic pain after physical immobilization, we analyzed pathophysiological mechanism using our chronic post-cast pain (CPCP) model. We found that oxidative damage, caused by two weeks cast immobilization, occurred in a wide area (muscle, muscle spindle and the like) of the immobilized hind limb. Also, our findings suggested the following: ①the oxidative damage induced hyper excitability of nociceptive neurons and neurogenic inflammation in the immobile limb; ②the neuropeptide signal generated by this neurogenic inflammation causes hyper-excitation of spinal dorsal horn neurons and causes central sensitization; ③ the behavior of mechanical hyperalgesia in the chronic phase is secondary to oxidative impairment in immobile limb.
|
