Association between objective assessment of physical activity during 40 weeks and brain volume

• Project/Area Number: 25750250
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: National Center for Geriatrics and Gerontology
• Principal Investigator: TSUTSUMIMOTO Kota 独立行政法人国立長寿医療研究センター, 生活機能賦活研究部, 研究員 (70633189)
• Research Collaborator: 鈴木 隆雄 桜美林大学, 教授 ; 島田 裕之 国立長寿医療研究センター, 部長 ; 牧迫 飛雄馬 国立長寿医療研究センター ; 土井 剛彦 国立長寿医療研究センター ; 李 相侖 国立長寿医療研究センター ; 阿南 祐也 活水女子大学, 助教 ; 上村 一貴 名古屋大学 ; 朴 眩泰 東亜大学 ; 安藤 啓司 神戸大学, 教授 ; 小野 玲 神戸大学, 准教授 ; 山田 実 筑波大学, 准教授 ; 浅井 剛 神戸学院大学, 助教
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 軽度認知障害 / 身体活動 / 脳容量

Outline of Final Research Achievements

The aim of this study was to investigate association between objective assessment of physical activity during 40 weeks and brain atrophy among mild cognitive impairment (MCI) in longitudinal observation study. Ninety four out of 134 participants had 70% or more available data of 40-weeks physical activity. Then, ninety four older adults with MCI were separated by quartile of total steps during 40 weeks (LOW, MID1, MID2, HIGH). Brain atrophy among participants was assessed before after the 40-weeks period using magnetic resonance imaging and specific software.In the result, The participants in HIGH group had significant lower atrophy of the bilateral medial temporal areas including the entorhinal cortex compared with those in LOW group.

Research Products

• [Journal Article] Objectively measured physical activity, brain atrophy, and white matter lesions in older adults with mild cognitive impairment. (2015)
  • Author(s): Doi T, Makizako H, Shimada H, Tsutsumimoto K, Hotta R, Nakakubo S, Park H, Suzuki T.
  • Journal Title: Experimental Gerontology Volume: 62 Pages: 1-6
  • DOI: 10.1016/j.exger.2014.12.011
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association of insulin-like growth factor-1 with mild cognitive impairment and slow gait speed (2015)
  • Author(s): Doi T, Shimada H, Makizako H, Tsutsumimoto K, Hotta R, Nakakubo S, Suzuki T
  • Journal Title: Neurobiology of Aging Volume: 36 Issue: 2 Pages: 942-947
  • DOI: 10.1016/j.neurobiolaging.2014.10.035
  • Peer Reviewed
• [Journal Article] Self-reported Exhaustion is Associated with Small Life Space in Older Adults with Mild Cognitive Impairment (2014)
  • Author(s): Tsutsumimoto K, Doi T, Shimada H, Makizako H, Uemura K, Ando H, Suzuki T.
  • Journal Title: Journal of Physical Therapy Science Volume: 26 Issue: 12 Pages: 1979-1983
  • DOI: 10.1589/jpts.26.1979
  • NAID: 130004834886
  • ISSN: 0915-5287, 2187-5626
  • Peer Reviewed
• [Journal Article] Association between toe flexor strength and spatiotemporal gait parameters in community-dwelling older people (2014)
  • Author(s): Misu S, Doi T, Asai T, Sawa R, Tsutsumimoto K, Nakakubo S, Yamada M, Ono R
  • Journal Title: Journal of NeuroEngineering and Rehabilitation Volume: 11 Issue: 1 Pages: 143-143
  • DOI: 10.1186/1743-0003-11-143
  • Peer Reviewed
• [Journal Article] Does arm swing emphasized deliberately increase the trunk stability during walking in the elderly adults? (2014)
  • Author(s): Nakakubo S, Doi T, Sawa R, Misu S, Tsutsumimoto K, Ono R
  • Journal Title: Gait & Posture Volume: 20 Issue: 4 Pages: 516-520
  • DOI: 10.1016/j.gaitpost.2014.06.005
  • Peer Reviewed
• [Journal Article] Effects of mild and global cognitive impairment on the prevalence of fear of falling in community-dwelling older adults (2014)
  • Author(s): Uemura K, Shimada H, Makizako H, Doi T, Tsutsumimoto K, Yoshida D, Anan Y, Ito T, Lee S, Park H, Suzuki T
  • Journal Title: Maturitas Volume: (In press) Issue: 1 Pages: 62-66
  • DOI: 10.1016/j.maturitas.2014.02.018
  • Peer Reviewed
• [Journal Article] The association between fear of falling and gait variability in both leg and trunk movements (2014)
  • Author(s): Sawa R, Doi T, Misu S, Tsutsumimoto K, Nakakubo S, Asai T, Yamada M, Ono R
  • Journal Title: Gait & Posture Volume: 40 Issue: 1 Pages: 123-127
  • DOI: 10.1016/j.gaitpost.2014.03.002
  • Peer Reviewed
• [Journal Article] A large, cross-sectional observational study of serum BDNF, cognitive function, and mild cognitive impairment in the elderly. (2014)
  • Author(s): Shimada H, Makizako H, Doi T, Yoshida D, Tsutsumimoto K, Anan Y, Uemura K, Lee S, Park H, Suzuki T
  • Journal Title: Frontiers in Aging Neuroscience Volume: (未定)(印刷中) Pages: 1-9
  • DOI: 10.3389/fnagi.2014.00069
  • Peer Reviewed / Open Access
• [Journal Article] Cognitive function and gait speed under normal and dual-task walking among older adults with mild cognitive impairment. (2014)
  • Author(s): Doi T, Shimada H, Makizako H, Tsutsumimoto K, Uemura K, Anan Y, Suzuki T.
  • Journal Title: BMC Neurology Volume: (未定)(印刷中) Issue: 1 Pages: 67-67
  • DOI: 10.1186/1471-2377-14-67
  • Peer Reviewed / Open Access
• [Journal Article] The combined status of physical performance and depressive symptoms is strongly associated with a history of falling in community-dwelling el derly : Cross-sectional findings from the Obu Study of Health Promotion for the Elderly (OSHPE) (2014)
  • Author(s): Makizako H, Shimada H, Doi T, Yoshida D, Tsutsumimoto K, Uemura K, Anan Y, Park H, Lee S, Ito T, Suzuki T
  • Journal Title: Arch Gerontol Geriatr Volume: 58(3) Issue: 3 Pages: 327-331
  • DOI: 10.1016/j.archger.2014.01.001
  • Peer Reviewed
• [Journal Article] Olfactory identification and cognitive performance in community-dwelling older adults with mild cognitive impairment (2014)
  • Author(s): Makizako M, Makizako H, Doi T, Uemura K, Tsutsumimoto K, Miyaguchi H, Shimada H
  • Journal Title: Chem Senses Volume: 39(1) Issue: 1 Pages: 39-46
  • DOI: 10.1093/chemse/bjt052
  • Peer Reviewed
• [Journal Article] Using two different algorithms to determine the prevalence of sarcopenia (2014)
  • Author(s): Yoshida D, Suzuki T, Shimada H, Park H, Makizako H, Doi T, Anan Y, Tsutsumimoto K, Uemura K, Ito T, et al
  • Journal Title: Geriatr Gerontol Int Volume: 14 Suppl 1 Issue: S1 Pages: 46-51
  • DOI: 10.1111/ggi.12210
  • Peer Reviewed
• [Journal Article] Can the Ordered Multi-Stepping Over Hoop test be useful for predicting fallers among older people? A preliminary 1 year cohort study (2013)
  • Author(s): Tsutsumimoto K, Doi T, Misu S, Ono R, Hirata S.
  • Journal Title: Aging Clinical and Experimental Research Volume: 25 Issue: 4 Pages: 427-432
  • DOI: 10.1007/s40520-013-0061-6
  • Peer Reviewed
• [Journal Article] Decreased skin temperature of the foot increases gait variability in healthy young adults (2013)
  • Author(s): Sawa R, Doi T, Misu S, Tsutsumimoto K, Fujino H, Ono R
  • Journal Title: Gait Posture Volume: in press Issue: 3 Pages: 518-522
  • DOI: 10.1016/j.gaitpost.2013.01.019
  • Peer Reviewed
• [Journal Article] Evaluation of multi-dimensional neurocognitive function for elderly populations using a tablet PC : Test-retest reliability and validity. (2013)
  • Author(s): Makizako H, Shimada H, Parte H, Doi T, Yoshida D, Uemura K, Tsutsumimoto K, Suzuki T
  • Journal Title: Geriatrics & Gerontology International Volume: (印刷中) Issue: 4 Pages: 860-866
  • DOI: 10.1111/ggi.12014
  • Peer Reviewed
• [Journal Article] Cognitive activities and instrumental activity of daily living in older adults with mild cognitive impairment (2013)
  • Author(s): Doi T, Shimada H, Makizako H, Lee S, Park H, Tsutsumimoto K, Uemura K Yoshida D, Anan Y, Suzuki T
  • Journal Title: Dement Geriatr Cogn Dis Extra Volume: 3(1) Issue: 1 Pages: 398-406
  • DOI: 10.1159/000355553
  • Peer Reviewed
• [Presentation] 健忘型軽度認知障害高齢者に対する複合的運動プログラムの効果検証 (2014)
  • Author(s): 土井剛彦, 島田裕之, 牧迫飛雄馬, 朴眩泰, 堤本広大, 鈴木隆雄
  • Organizer: 第4回日本認知症予防学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-09-26 – 2014-09-28
• [Presentation] 自覚的疲労感と機能低下との関係 ―高齢期における年代別にみた特徴 (2014)
  • Author(s): 堤本広大, 土井剛彦, 島田裕之, 牧迫飛雄馬, 吉田大輔, 阿南祐也, 上村一貴, 堀田亮, 中窪翔, 朴眩泰, 鈴木隆雄
  • Organizer: 第49回日本理学療法学術大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-05-30 – 2014-06-01
• [Presentation] 地域在住自立高齢者における肥満と歩行能力，身体活動量の関連 (2014)
  • Author(s): 杉本大貴, 堤本広大, 澤龍一, 中津伸之, 上田雄也, 斉藤貴, 中村凌, 村田峻輔, 山崎蓉子, 中窪翔, 土井剛彦, 小野玲
  • Organizer: 第49回日本理学療法学術大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-05-30 – 2014-06-01
• [Presentation] 軽度認知機能障害と運動機能低下は相互作用により転倒との関連性が強くなるのか？―歩行解析と認知機能評価による検討― (2014)
  • Author(s): 土井剛彦, 島田裕之, 牧迫飛雄馬, 朴眩泰, 吉田大輔, 堤本広大, 上村一貴, 阿南祐也, 鈴木隆雄.
  • Organizer: 第49回日本理学療法学術大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-05-30 – 2014-06-01
• [Presentation] Self-reported Exhaustion among Older Adults with Mild Cognitive Impairment; Physical Function, Physical Activity Life Space. (2013)
  • Author(s): 1） Tsutsumimoto K, Doi T, Shimada H, Makizako H, Yoshida D, Anan Y, Uemura K, Lee S, Park H, Suzuki T.
  • Organizer: The 20th IAGG World Congress of Gerontology and Geriatrics
  • Place of Presentation: Seoul, Korea
• [Presentation] Gait Ability and Congnitive Function Among Older Adults With Mild Cognitive Impairments (2013)
  • Author(s): 2） Doi T, Shimada H, Makizako H, Tsutsumimoto K, Uemura K, Anan Y, Nakakubo S, Suzuki T
  • Organizer: The 20th IAGG World Congress of Gerontology and Geriatrics
  • Place of Presentation: Seoul, Korea
• [Presentation] National study of performance-based assessments and personal care in Japanese older people (2013)
  • Author(s): 3） Suzuki T, Shimada H, Suzukawa M, Makizako H, Tsutsumimoto K, Anan Y, Doi T, Yoshida D, Uemura K, Ito T, Lee S, Park H
  • Organizer: The 20th IAGG World Congress of Gerontology and Geriatrics
  • Place of Presentation: Seoul, Korea
• [Presentation] グループ単位の運動介入実施により軽度認知障害を有する高齢者のQOLは向上するのか？ ─ランダム化比較試験による検討─ (2013)
  • Author(s): 堤本広大, 土井剛彦, 島田裕之, 牧迫飛雄馬, 吉田大輔, 上村一貴, 阿南祐也, 伊藤忠, 李相侖, 朴眩泰, 鈴木隆雄
  • Organizer: 第48回日本理学療法学術大会
  • Place of Presentation: 名古屋