| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Endurance exercise training induced glucose transporter GLUT-4 biogenesis in skeletal muscle, leading to improved whole-body insulin sensitivity. The purpose of this study was to examine the hypothesis that individuals with a history of previous endurance training can easily acquire the metabolic adaptation in skeletal muscle on retraining. This study showed that in rat skeletal muscle that had experienced endurance exercise training, GLUT-4 gene was upregulated rapidly in response to acute bout of exercise after detraining. These results suggest that effects of previous endurance exercise training can be retained as “metabolic memory” or “muscle memory”. The results observed in this study also suggest that histone hyperacetylation may not be involved in the endurance exercise training-induced metabolic memory in skeletal muscle.
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