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Elucidation of the mechanisms of skeletal muscle mitochondrial biogenesis by lactate

Research Project

Project/Area Number 25750331
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Sports science
Research InstitutionThe University of Tokyo

Principal Investigator

Hoshino Daisuke  東京大学, 大学院理学系研究科(理学部), 特任助教 (70612117)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords乳酸 / ミトコンドリア / 運動 / 転写制御 / 骨格筋
Outline of Final Research Achievements

We examined whether lactate causes skeletal muscle mitochondrial biogenesis, using extracted mouse muscle incubation system and electric stimulation system to C2C12 myotubes. As a result, 24h-lactate stimulation (10 mM) for extracted mouse muscle suppressed mRNA contents of PGC-1alpha and mitochondria. However lactate concentration exceeded 25 mM after 24 hours of lactate incubation, which was non-physiological high lactate concentration. Elevation in lactate concentration due to electrical stimulation increased the mRNA contents of PGC-1alpha in C2C12 myotubes. These results suggest that the increase in lactate concentration associated with muscle contraction may cause mitochondrial biogenesis via transcriptional regulation. It is necessary to clarify the dose response of lactate concentration in further studies.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (14 results)

All 2016 2015 2014 2013

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (7 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Exercise-induced expression of monocarboxylate transporter 2 in the cerebellum and its contribution to motor performance.2016

    • Author(s)
      Daisuke Hoshino, Susumu Setogawa, Yu Kitaoka, Hiroyuki Masuda, Yuki Tamura, Hideo Hatta, Dai Yanagihara.
    • Journal Title

      Neurosci Lett

      Volume: 633 Pages: 1-6

    • DOI

      10.1016/j.neulet.2016.09.012

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] High-intensity interval training enhances oxidative capacity and substrate availability in skeletal muscle2016

    • Author(s)
      Daisuke Hoshino, Yu Kitaoka, Hideo Hatta
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 5 Issue: 1 Pages: 13-23

    • DOI

      10.7600/jpfsm.5.13

    • NAID

      130005138386

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of decreased lactate accumulation after dichloroacetate administration on exercise training-induced mitochondrial biogenesis in mouse skeletal muscle2015

    • Author(s)
      Daisuke Hoshino, Yuki Tamura, Hiroyuki Masuda, Yutaka Matsunaga, Hideo Hatta
    • Journal Title

      Physiol Rep

      Volume: 3 Issue: 9 Pages: e12555-e12555

    • DOI

      10.14814/phy2.12555

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pre-exercise casein peptide supplementation enhances endurance training-induced mitochondrial enzyme activity in slow twitch muscle, but not fast twitch muscle of high fat diet-fed mice2015

    • Author(s)
      Yutaka Matsunaga, Yuki Tamura, Yumiko Takahashi, Hiroyuki Masuda, Daisuke Hoshino, Yu Kitaoka, Noriko Saito, Hirohiko Nakamura, Yasuhiro Takeda, Hideo Hatta
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 4 Issue: 5 Pages: 377-384

    • DOI

      10.7600/jpfsm.4.377

    • NAID

      130005113193

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Daily heat stress treatment rescues denervation-activated mitochondrial clearance and atrophy in skeletal muscle2015

    • Author(s)
      Yuki Tamura, Yu Kitaoka, Yutaka Matsunaga, Daisuke Hoshino, Hideo Hatta
    • Journal Title

      J Physiol

      Volume: 593 Issue: 12 Pages: 2707-2720

    • DOI

      10.1113/jp270093

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chronic Post-Exercise Lactate Administration with Endurance Training Increases Glycogen Concentration and Monocarboxylate Transporter 1 Protein in Mouse White Muscle2014

    • Author(s)
      Daisuke Hoshino, Tatsuya Hanawa, Yumiko Takahashi, Hiroyuki Masuda, Mai Kato, Hideo Hatta.
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: 60 Issue: 6 Pages: 413-419

    • DOI

      10.3177/jnsv.60.413

    • NAID

      130005060911

    • ISSN
      0301-4800, 1881-7742
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Post-exercise whole-body heat stress additively enhances endurance training-induced mitochondrial adaptations in mouse skeletal muscle2014

    • Author(s)
      Yuki Tamura, Yutaka Matsunaga, Hiroyuki Masuda, Yumiko Takahashi, Yuki Takahashi, Shin Terada, Daisuke Hoshino, Hideo Hatta.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 307 Issue: 7 Pages: R931-R943

    • DOI

      10.1152/ajpregu.00525.2013

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Dynamics of metabolomic profile in response to electrical stimulation-induced muscle contractions in C2C12 myotubes.2016

    • Author(s)
      Daisuke Hoshino, Katsuyuki Kunida, Takumi Wada, Atsushi Hatano, Katsuyuki Yugi, Shinya Kuroda
    • Organizer
      The Advanced Lecture Course on Systems Biology
    • Place of Presentation
      インスブルック (オーストリア)
    • Year and Date
      2016-02-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 高強度インターバルトレーニングによる骨格筋ミトコンドリアの適応と乳酸2016

    • Author(s)
      星野太佑、八田秀雄
    • Organizer
      第168回日本体力医学会関東地方会
    • Place of Presentation
      首都大学東京 (東京都・荒川区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Different cellular responses between continuous and intermittent muscle contractions by electrical stimulation in C2C12 myotubes2015

    • Author(s)
      Daisuke Hoshino, Katsuyuki Kunida, Takumi Wada, Atsushi Hatano, Shinya Kuroda
    • Organizer
      The 16th International Conference on Systems Biology
    • Place of Presentation
      Biopolis (シンガポール)
    • Year and Date
      2015-11-23
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] C2C12 myotubesに対する電気刺激によるシグナル分子のリン酸化の時系列変化2015

    • Author(s)
      星野太佑
    • Organizer
      第16回日本運動生理学会大会
    • Place of Presentation
      日本体育大学 (東京都世田谷区)
    • Year and Date
      2015-07-25
    • Related Report
      2015 Research-status Report
  • [Presentation] 電気刺激によるシグナル分子のリン酸化の時系列変化-C2C12を用いた検討-2015

    • Author(s)
      星野太佑、国田勝行、和田卓巳、黒田真也
    • Organizer
      第3回骨格筋生物学研究会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-03-06 – 2015-03-08
    • Related Report
      2014 Research-status Report
  • [Presentation] Acute exercise increases monocarboxylate transporter 2 expression in mouse cerebellum2013

    • Author(s)
      Daisuke Hoshino, Yu Kitaoka, Osamu Setogawa, Hiroyuki Masuda, Yuki Tamura, Dai Yanagihara, Hideo Hatta.
    • Organizer
      Experimental Biology 2013
    • Place of Presentation
      Boston Convention and Exhibition Center (アメリカ ボストン)
    • Related Report
      2013 Research-status Report
  • [Presentation] ジクロロ酢酸摂取による運動中の乳酸蓄積の低下はミトコンドリアの増加を減衰させる2013

    • Author(s)
      星野太佑, 田村優樹, 増田紘之, 八田秀雄
    • Organizer
      第68回日本体力医学会大会
    • Place of Presentation
      日本教育会館(東京都千代田区)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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