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Effects of fiber-rich diet with brown rice on endothelial function

Research Project

Project/Area Number 25750346
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied health science
Research InstitutionShiga University of Medical Science

Principal Investigator

KONDO KEIKO  滋賀医科大学, 医学部, 特任助教 (20566567)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords食事介入 / 玄米 / 血管内皮機能 / 2型糖尿病 / 食物繊維 / 糖尿病
Outline of Final Research Achievements

Twenty-eight patients with type 2 diabetes mellitus were randomly assigned to a brown rice (n=14) or white rice (n=14) diet and were followed for 2 months. After intervention, both groups were followed by white rice diet for 2 months.
In the brown rice group, the intake of dietary fiber increased after the intervention and decreased after the follow-up period. The levels of fasting plasma glucose, glycoalbumin, and, total and LDL-cholesterol improved after the intervention and returned to the baseline levels after the follow-up period in brown rice group. Endothelial function significantly improved after the intervention and these effects were sustained after the follow-up period in the brown rice group, although metabolic parameters were returned to the baseline levels after the follow-up period.
This study suggested the intervention with brown rice improves endothelial function. The effect was sustained for an additional 2 months after stopping the intervention in type 2 diabetes.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2017 2015 2014

All Presentation (7 results) Funded Workshop (1 results)

  • [Presentation] Post-prandial Improvement in Endothelial Function by Brown Rice Diet Intervention in Patients with Type 2 Diabetes Mellitus.2015

    • Author(s)
      Keiko Kondo, Katsutaro Morino, Atsushi Ishikado, Keiko Nakao, Fumiyuki Nakagawa, Fumio Nikami, Osamu Sekine, Ken-ichi Nemoto, Makoto Suwa, Motonobu Matsumoto, Taketoshi Makino, Atsunori Kashiwagi, Satoshi Ugi, Hiroshi Maegawa
    • Organizer
      The 75th American Diabetes Association
    • Place of Presentation
      Boston, MA, America
    • Year and Date
      2015-06-05
    • Related Report
      2015 Research-status Report
  • [Presentation] 糖尿病患者において玄米を用いた高繊維食は血管内皮機能を改善する2015

    • Author(s)
      近藤慶子、森野勝太郎、石角 篤、中尾恵子、中川史之、仁神史生、関根 理、根本憲一、諏訪 淳、松本元伸、牧野武利、柏木厚典、卯木 智、前川 聡
    • Organizer
      第58回 日本糖尿病学会年次学術集会
    • Place of Presentation
      山口
    • Year and Date
      2015-05-21
    • Related Report
      2015 Research-status Report
  • [Presentation] Improvement of Endothelial Function by Brown Rice Diet was Associated with Change of Gut Microflora Composition in Patients with Type 2 Diabetes Mellitus.2014

    • Author(s)
      Keiko Kondo, Katsutaro Morino, Atsushi Ishikado, Keiko Nakao, Fumio Nikami, Osamu Sekine, Ken-ichi Nemoto, Motonobu Matsumoto, Taketoshi Makino, Atsunori Kashiwagi, Satoshi Ugi, Hiroshi Maegawa
    • Organizer
      The 74th American Diabetes Association
    • Place of Presentation
      San Francisco, CA, America
    • Year and Date
      2014-06-13 – 2014-06-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 玄米を用いた高繊維食は糖尿病患者の血管内皮機能を改善する2014

    • Author(s)
      近藤慶子, 森野勝太郎, 石角 篤, 中尾恵子, 仁神史生, 関根 理, 根本憲一, 松本元伸, 牧野武利, 柏木厚典, 卯木 智, 前川 聡
    • Organizer
      第57回 日本糖尿病学会年次学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 玄米を用いた高繊維食が血管機能に及ぼす影響2014

    • Author(s)
      近藤慶子
    • Organizer
      病態栄養学会年次学術集会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] 玄米を用いた高繊維食は糖尿病患者の血管内皮機能を改善する2014

    • Author(s)
      近藤慶子
    • Organizer
      糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] Improvement of Endothelial Function by Brown Rice Diet was Associated with Change of Gut Microflora Composition in Patients with Type 2 Diabetes Mellitus.2014

    • Author(s)
      Keiko Kondo
    • Organizer
      American Diabetes Association
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2013 Research-status Report
  • [Funded Workshop] AHA EPI LifeStyle2017

    • Place of Presentation
      アメリカ、ポートランド
    • Year and Date
      2017-03-06
    • Related Report
      2016 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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