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Magnetoencephalography study aimed to clarify the neural mechanisms of fatigue sensation by assessing functional relationships among brain regions related to multiple aspects of fatigue sensation

Research Project

Project/Area Number 25750351
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied health science
Research InstitutionOsaka City University

Principal Investigator

Ishii Akira  大阪市立大学, 大学院医学研究科, 病院講師 (90587809)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords疲労 / 疲労感 / 疲労の認知 / 脳磁図 / 疲労感の想起 / 身体的な疲労 / 記憶 / 意志決定 / 後帯状回 / 背外側前頭前野
Outline of Final Research Achievements

We aimed to clarify the neural mechanisms of fatigue sensation by assessing functional relationships, using magnetoencephalography with high temporal and spatial resolutions, among brain regions related to multiple aspects of fatigue sensation. We focused on the neural mechanisms related to the re-experience of mental and physical fatigue sensation, the making decision to rest in the presence of fatigue, and the prediction of the level of fatigue sensation in the future. Our results showed that the neural mechanisms of the decision to rest in the presence of fatigue and those of the prediction of the future level of fatigue were related to those of the re-experience of fatigue sensation and those of the self-evaluation of the level of fatigue sensation. These findings may help in the understanding of the pathophysiology of fatigue and fatigue-related conditions and/or diseases.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2015 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 4 results,  Open Access: 3 results) Presentation (7 results) (of which Invited: 1 results)

  • [Journal Article] 脳磁図を用いた疲労の脳科学研究2015

    • Author(s)
      田中雅彰,石井聡,渡辺恭良
    • Journal Title

      日本疲労学会誌

      Volume: 10 Pages: 1-5

    • Related Report
      2015 Annual Research Report
  • [Journal Article] The neural mechanisms of re-experiencing mental fatigue sensation: a magnetoencephalography study2015

    • Author(s)
      Ishii A, Karasuyama T, Kikuchi T, Tanaka M, Yamano E, Watanabe Y
    • Journal Title

      PLoS One

      Volume: 10 Issue: 3 Pages: 1-11

    • DOI

      10.1371/journal.pone.0122455

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The neural substrates of physical fatigue sensation to evaluate ourselves: a magnetoencephalography study2014

    • Author(s)
      Ishii A, Tanaka M, Yamano E, Watanabe Y
    • Journal Title

      Neuroscience

      Volume: 261 Pages: 60-67

    • DOI

      10.1016/j.neuroscience.2013.12.049

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The neural substrates of self-evaluation of mental fatigue: a magnetoencephalography study2014

    • Author(s)
      Ishii A, Tanaka M, Watanabe Y
    • Journal Title

      PLoS One

      Volume: 9 Issue: 4 Pages: 1-7

    • DOI

      10.1371/journal.pone.0095763

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The neural mechanisms underlying the decision to rest in the presence of fatigue: a magnetoencephalography study2014

    • Author(s)
      Ishii A, Tanaka M, Watanabe Y
    • Journal Title

      PLoS One

      Volume: 9 Issue: 10 Pages: 1-8

    • DOI

      10.1371/journal.pone.0109740

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Neural effects of prolonged mental fatigue: a magnetoencephalography study2013

    • Author(s)
      Ishii A, Tanaka M, Shigihara Y, Kanai E, Funakura M, Watanabe Y
    • Journal Title

      Brain Research

      Volume: 1529 Pages: 105-112

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] The neural substrates of imaging mental fatigue: a magnetoencephalography study2015

    • Author(s)
      石井 聡、田中 雅彰、山野 恵美、渡辺 恭良
    • Organizer
      第38回神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脳磁図による疲労の神経メカニズムの研究2015

    • Author(s)
      石井 聡、田中 雅彰、山野 恵美、渡辺 恭良
    • Organizer
      第11回日本疲労学会総会
    • Place of Presentation
      山口県総合保健会館(山口県山口市)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Neural mechanisms of fatigue2015

    • Author(s)
      Akira Ishii, Masaaki Tanaka, Emi Yamano, Yasuyoshi Watanabe
    • Organizer
      第92回 日本生理学会大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県・神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] The neural substrates of making decisions to maintain task performance based on the level of fatigue: a magnetoencephalography study2014

    • Author(s)
      Akira Ishii, Masaaki Tanaka, Emi Yamano, Yasuyoshi Watanabe
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 精神的疲労の評価に関わる神経メカニズムの脳磁図研究2014

    • Author(s)
      石井聡、田中雅彰、山野恵美、渡辺恭良
    • Organizer
      第10回日本疲労学会
    • Place of Presentation
      グランフロント大阪(大阪府・大阪市)
    • Year and Date
      2014-05-30 – 2014-05-31
    • Related Report
      2014 Research-status Report
  • [Presentation] 身体的疲労の評価に関わる神経メカニズムの脳磁図研究2013

    • Author(s)
      石井聡、田中雅彰、山野恵美、渡辺恭良
    • Organizer
      第9回日本疲労学会
    • Place of Presentation
      秋田県総合保健センター
    • Related Report
      2013 Research-status Report
  • [Presentation] Neural substrates related to physical fatigue sensation for the evaluation of ourselves: a magnetoencephalography study2013

    • Author(s)
      Akira Ishii, Masaaki Tanaka, Emi Yamano, Yasuyoshi Watanabe
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都国際会館
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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