Analysis of relationships between the changing amount of skatole, an enterobacterium-derived dietary protein metabolite, and liver functions.
Project/Area Number |
25750356
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Applied health science
|
Research Institution | Hokkaido University |
Principal Investigator |
SHIMIZU Hidehisa 北海道大学, (連合)農学研究科(研究院), 特任講師 (10547532)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | スカトール / 回腸 / タウロコール酸 / 抱合型胆汁酸 / デオキシコール酸 / 二次胆汁酸 / 動物性タンパク質 / 腸内細菌代謝物 / 胆汁酸 / 生活習慣病 / トリプトファン代謝物 / 腸内細菌 |
Outline of Final Research Achievements |
In the present study, we analyzed the effect of skatole on the liver functions. Male SD rats were fed a diet supplemented with or without skatole for 28 days. The ingestion of skatole modulated bile acid metabolism, which is mainly regulated in the liver. However, inflammatory response may be not initiated during this ingestion period because the expression level of TNF alpha, one of the inflammatory cytokine genes, in the liver, ileum, and colon was not changed between control and the Skatole-fed rats. Furthermore, the present study also examined whether modulated bile acid metabolism influences the initiation and progression of atherosclerosis. Deoxycholic acid, a representative secondary bile acid, enhanced proliferation and migration of vascular smooth muscle cells. Taken together, it is possible that change of bile acid metabolism by increased skatole concentration in gastrointestinal tract is involved in the pathogenesis of atherosclerosis.
|
Report
(3 results)
Research Products
(6 results)
-
[Journal Article] Deoxycholic Acid Is Involved in the Proliferation and Migration of Vascular Smooth Muscle Cells2014
Author(s)
Shimizu H, Hagio M, Iwaya H, Tsuneki I, Lee JY, Fukiya S, Yokota A, Miyazaki H, Hara H, Ishizuka S
-
Journal Title
Journal of Nutritional Science and Vitaminology
Volume: 60
Issue: 6
Pages: 450-454
DOI
NAID
ISSN
0301-4800, 1881-7742
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
-
[Presentation] Skatole, an intestinal bacteria-derived dietary protein metabolite, increases concentration of fecal deoxycholic acid-related bile acids and ileal taurocholic acid.2014
Author(s)
Shimizu, H., Hagio, M., Nose, T., Lee, JY., Fukiya, S., Yokota, A., Hara, H., Ishizuka, S.
Organizer
17th IUFoST World Congress of Food Science and Technology and EXPO
Place of Presentation
Montreal Convention Centre(カナダ)
Year and Date
2014-08-17 – 2014-08-21
Related Report
-