| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
In the present study, we analyzed the effect of skatole on the liver functions. Male SD rats were fed a diet supplemented with or without skatole for 28 days. The ingestion of skatole modulated bile acid metabolism, which is mainly regulated in the liver. However, inflammatory response may be not initiated during this ingestion period because the expression level of TNF alpha, one of the inflammatory cytokine genes, in the liver, ileum, and colon was not changed between control and the Skatole-fed rats. Furthermore, the present study also examined whether modulated bile acid metabolism influences the initiation and progression of atherosclerosis. Deoxycholic acid, a representative secondary bile acid, enhanced proliferation and migration of vascular smooth muscle cells. Taken together, it is possible that change of bile acid metabolism by increased skatole concentration in gastrointestinal tract is involved in the pathogenesis of atherosclerosis.
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