| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The aim of this study was to investigate the relationship between reactive oxygen species (ROS) and iron metabolism in age-related disturbance of iron metabolism. It was shown that the 2,3-Dimethoxy-1,4-naphtoquinone (DMNQ), a superoxide generator, and ammonium tetrathiomolybdate (TTMo), an inhibitor of superoxide dismutase, induced the phosphorylation of iron regulatory protein 1 (IRP1) via protein kinase C (PKC) activation. In addition, treatment with 4-hydroxy-s-nonenal (4-HNE), an end products of lipid peroxidation, inhibited IRP1 activity and caused a decrease in expression of iron transporters. These results suggest that ROS control iron metabolism through IRP1 regulation.
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