| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
It has been reported that tissue taurine depletion accelerates skeletal muscle aging accompanied with enhancement of the phosphorylation of ribosomal protein S6 subunit (RPS6), which is a downstream target of mTOR, an aging-related signal protein. In the present study, we investigated the signaling pathway involved in RPS6 phosphorylation to reveal the mechanism of aging acceleration. We identified that signaling pathway responsible for unfolded protein response are activated in taurine-depleted mouse, suggesting the accumulation of endoplasmic reticulum stress by tissue taurine depletion. Moreover, we found that endoplasmic reticulum stress induces the phosphorylation of RPS6 in skeletal muscle cells. These results suggest that taurine depletion causes RPS6 phosphorylation through ER stress accumulation and then accelerates skeletal muscle aging.
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