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Daily physical activity or exercise habit and the gene polymorphisms on dopamine system.

Research Project

Project/Area Number 25750371
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied health science
Research InstitutionNational Institute of Health and Nutrition

Principal Investigator

MURAKAMI Haruka  独立行政法人国立健康・栄養研究所, 健康増進研究部, 研究員 (20344880)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords身体活動 / 運動 / 遺伝 / ドーパミン / 行動 / 運動習慣 / ドーパミンシステム / 遺伝子多型
Outline of Final Research Achievements

The porpose of this study was to investigate the relation between daily physical activity or exercise habit and the gene polymorphisms on dopamine system. Eighty-hundred one healthy adults and 604 athletes participated in this study. DRD2/ANKK1 gene polymorphism rs1800497 was associated with exercise habit in the period from childhood to adolescence. This polymorphism was also associated with athlete level only in male athletes, but not in female athletes. The T allele was associated with an increased likelihood of the international/national level in the additive genetic model (OR = 1.67, 95%CI: 1.15-2.41). Moreover the other two polymorphisms on DRD2 gene was associated with daily physical activity assessed using tri-accelerometer. it was suggested that the dopamine system is involved in determination of daily physical activity or exercise habit.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report

Research Products

(8 results)

All 2015 2014 Other

All Journal Article Presentation

  • [Journal Article] Circulating leptin levels are associated with physical activity or physical fitness in Japanese2014

    • Author(s)
      Miyatake N, Murakami H, Kawakami R, Tabata I, Miyachi M; The NEXIS Study Group.
    • Journal Title

      Environ Health Prev Med

      Volume: 19 Issue: 5 Pages: 362-366

    • DOI

      10.1007/s12199-014-0398-2

    • NAID

      50009312843

    • ISSN
      1342-078X, 1347-4715
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Q223R Polymorphism in the Leptin Receptor Associates With Objectively Measured Light Physical Activity in Free-living Japanese.2014

    • Author(s)
      Murakami H, Iemitsu M, Fuku N, Sanada K, Gando Y, Kawakami R, Miyachi M.
    • Journal Title

      Physiol. Behav.

      Volume: 19 Pages: 1421-1428

    • DOI

      10.1016/j.physbeh.2014.02.053

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Association between DRD2 Genotypes and Exercise Habits.2015

    • Author(s)
      Murakami H, Fuku N, Iemitsu M, Sanada K, Kawakami R, Gando Y, Miyachi M.
    • Organizer
      62nd American College of Sports Medicine
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2015-05-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] これ以上の身体活動低下を防ぐための社会環境の整備と改善:身体活動・運動行動に影響を及ぼす遺伝要因.2014

    • Author(s)
      村上晴香
    • Organizer
      第73回日本公衆衛生学会
    • Place of Presentation
      栃木県総合文化センター(栃木県・宇都宮市)
    • Year and Date
      2014-11-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 日常身体活動量の個人差とドーパミン受容体(DRD2)遺伝子多型との関連.2014

    • Author(s)
      村上晴香, 福典之, 川上諒子, 丸藤祐子, 家光素行,真田樹義, 宮地元彦
    • Organizer
      第69回日本体力医学会
    • Place of Presentation
      長崎大学(長崎県・長崎市)
    • Year and Date
      2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effect of DRD2/ANKK1 genotype on exercise behavior and performance in Japanese athlete and control.2014

    • Author(s)
      Murakami H, Fuku N, Iemitsu M, Sanada K, Kawakami R, Gando Y, Miyachi M.
    • Organizer
      61st American College of Sports Medicine
    • Place of Presentation
      Orlando (USA)
    • Year and Date
      2014-05-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 身体活動増大を目的とした介入による身体活動量の変化とドーパミン遺伝子多型との関連

    • Author(s)
      村上晴香, 福典之, 川上諒子, 丸藤祐子, 塙智史, 宮地元彦
    • Organizer
      第68回日本体力医学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Effects of dopamine D2 receptor gene polymorphism on physical activity level in humans

    • Author(s)
      Murakami H, Iemitsu M, Sanada K, Fuku N, Kawakami R, Gando Y, Miyachi M
    • Organizer
      60th American College of Sports Medicine
    • Place of Presentation
      Indianapolice、USA
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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