Study on glucose uptake enhancement activity of plant derived compounds with unique and high polar structure
| Project/Area Number |
25750391
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical biology
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| Research Institution | Hokkaido University |
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Principal Investigator |
KATO Eisuke 北海道大学, (連合)農学研究科(研究院), 講師 (40466446)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 糖尿病 / 糖取り込み促進物質 / 骨格筋 / アドレナリン / ピペリン / 不飽和脂肪酸 / アドレナリン受容体 / ヒゲナミン / Lepidium meyenii / Piper nigrum / 糖取り込み促進 / 筋細胞 |
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| Outline of Final Research Achievements |
Diabetes mellitus is a disease that shows high blood glucose level. The disease is currently considered a worldwide problem and development of a method for treatment is highly required task. However, current medicines are developed on a intense to control blood glucose and prevent complications and thus, they are not suitable for completely curing the disease. In this study, bioactive compound that enhance the glucose uptake of muscle cells are studied as a candidate for diabetes mellitus curing compound. The function of the glucose uptake enhancer neohesperidose was revealed and several new glucose uptake enhancers including higenamine glucoside, hydroxylamine, unsaturated fatty acids, piperine were discovered. Also, the function of higenamine glucoside, hydroxylamine are revealed from inhibitor co-incubation experiment.
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Report
(4 results)
Research Products
(15 results)
