| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Transforming growth factor-β (TGF-β) regulate various kinds of biological phenomena, such as cell growth, apoptosis and so on. The purpose of this study is developing the novel method to regulate this signal. We developed the phosphorylated Smad2 recognition peptide using dynamic combinatorial chemistry. We also investigated the regulation of TGF-β signal by controlling the function of translational modification sugar on TGF receptor. For this purpose we developed the molecule which bind to core fucose and which inhibit the formation of core fucose.
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