Synthesis and regulation of the phosphorylated signal in vivo template assisted synthesis
| Project/Area Number |
25750394
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical biology
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| Research Institution | Osaka University |
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Principal Investigator |
Manabe Yoshiyuki 大阪大学, 理学(系)研究科(研究院), 助教 (00632093)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | TGF-β / 翻訳後修飾糖鎖 / コアフコース / 動的コンビナトリアルケミストリー / FUT8 / ケミカルバイオロジー / Smad / リン酸化シグナル / コンビナトリアルケミストリー / N-グリカン |
|---|
| Outline of Final Research Achievements |
Transforming growth factor-β (TGF-β) regulate various kinds of biological phenomena, such as cell growth, apoptosis and so on. The purpose of this study is developing the novel method to regulate this signal. We developed the phosphorylated Smad2 recognition peptide using dynamic combinatorial chemistry. We also investigated the regulation of TGF-β signal by controlling the function of translational modification sugar on TGF receptor. For this purpose we developed the molecule which bind to core fucose and which inhibit the formation of core fucose.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] Facile Preparation of 1,5-Diazacyclooctanes from Unsaturated Imines: Effects of the Hydroxyl Groups on [4+4] Dimerization2014
Author(s)
Tanaka, K., Matsumoto, R., Pradipta, A. R., Kitagawa, Y., Okumura, M. Manabe. Y., Fukase, K.
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Journal Title
Synlett
Volume: 25
Issue: 07
Pages: 1026-1030
DOI
Related Report
Peer Reviewed
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[Presentation] Efficient Synthesis of Complex-Type N-Glycans2015
Author(s)
Masahiro Nagasaki, Naoya Minamoto, Hiroki Shomura, Yoshiyuki Manabe, Katsunori Tanaka, Koichi Fukase
Organizer
the 13th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-13)
Place of Presentation
Kyoto
Year and Date
2015-11-09
Related Report
Int'l Joint Research
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[Presentation] Synthetic Study of Highly Complicated N-glycans2013
Author(s)
Yoshiyuki Manabe, Jiazhou Zhou, Masahiro Nagasaki, Naoya Minamoto, Katsunori Tanaka, Koichi Fukase
Organizer
The 8th international conference on cutting-edge organic chemistry in Asia / The 4th new phase international conference on cutting-edge organic chemistry (ICCEOCA-8 / NICCEOCA-4)
Place of Presentation
大阪
Related Report
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