Investigation of network-level effect after perturbation of eye movement related cortical areas through optogenetics and fMRI in macaques

• Project/Area Number: 25750399
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Basic / Social brain science
• Research Institution: Niigata University (2014-2015); The University of Tokyo (2013)
• Principal Investigator: Adachi Yusuke 新潟大学, 医歯学系, 助教 (40625646)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: マカクザル / 機能的核磁気共鳴画像法 / 大脳皮質不活性化 / functional connectivity / 大脳皮質 / マカクサル / fMRI / 皮質不活性化 / 領野間ネットワーク / 光遺伝学

Outline of Final Research Achievements

The cerebral cortex is a functional network consisting of a vast number of long-range interactions between brain areas, and the influence at the level of this global network in consequence of local cortical inactivation remains unclear. We reversibly inactivated the macaque prearcuate cortex during functional magnetic resonance imaging experiments and detected the global influence on the network of functional connectivity (FC) between cortical areas across the whole brain. Our results showed that quantitative relations exist between the changes in FC between distant areas and the FC between the inactivated site and these areas in the no-inactivation condition, even in area pairs remote from the inactivated site.

Research Products

• [Journal Article] Dynamically allocated hub in task-evoked network predicts the vulnerable prefrontal locus for contextual memory retrieval in macaques. (2015)
  • Author(s): Osada T., Adachi, Y., Miyamoto, K., Jimura, K., Setsuie, R., and Miyashita, Y.
  • Journal Title: PLOS Biology Volume: 13(6) Issue: 6 Pages: 1-31
  • DOI: 10.1371/journal.pbio.1002177
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] op-down regulation of laminar circuit via inter-area signal for successful object memory recall in monkey temporal cortex. (2015)
  • Author(s): Takeda, M., Koyano, W.K., Hirabayashi, T., Adachi, Y. and Miyashita,Y.
  • Journal Title: Neuron Volume: 印刷中 Issue: 3 Pages: 840-852
  • DOI: 10.1016/j.neuron.2015.03.047
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Remapping of memory encoding and retrieval networks: insights from neuroimaging in primates. (2014)
  • Author(s): Miyamoto, K., Osada, T., Adachi, Y.
  • Journal Title: Behavioural Brain Research Volume: 275 Pages: 53-61
  • DOI: 10.1016/j.bbr.2014.08.046
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A design strategy for small molecule-based targeted MRI contrast agents: Their application for detection of atherosclerotic plaques (2014)
  • Author(s): Iwaki, S.; Hokamura, K.; Ogawa, M.; Takehara, Y.; Muramatsu, Y.; Yamane, T.; Hirabayashi, K.; Morimoto, Y.; Hagisawa, K.; Nakahara, K.; Mineno, T.; Terai, T.; Komatsu, T.; Ueno, T.; Tamura, K,; Adachi, Y.; Hirata, Y.; Arita, M.; Arai, H.; Umemura, K.; Nagano T. and Hanaoka K.
  • Journal Title: Organic & Biomolecular Chemistry Volume: 12 Issue: 43 Pages: 8611
  • DOI: 10.1039/c4ob01270d
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Dissociable memory traces within the macaque medial temporal lobe predict subsequent recognition performance. (2014)
  • Author(s): Miyamoto, K., Adachi, Y., Osada, T., Watanabe, T., Kimura, HM., Setsuie, R., Miyashita, Y.
  • Journal Title: The Journal of Neuroscience Volume: 34 Issue: 5 Pages: 1988-1997
  • DOI: 10.1523/jneurosci.4048-13.2014
  • Peer Reviewed / Open Access
• [Journal Article] Functional differentiation of memory retrieval network in macaque posterior parietal cortex (2013)
  • Author(s): Miyamoto, K., Osada, T., Adachi, Y., Matsui, T., Kimura, HM. Miyashita
  • Journal Title: Neuron Volume: 77 Issue: 4 Pages: 787-799
  • DOI: 10.1016/j.neuron.2012.12.019
  • Peer Reviewed
• [Presentation] Inter-area signal targeting translaminar processing during successful memory retrieval in macaque temporal cortex (2015)
  • Author(s): Takeda M, Koyano KW, Hirabayashi T, Adachi Y, Ishii T, Miyashita Y
  • Organizer: Neuroscience 2016
  • Place of Presentation: McCormick Place (Chicago, IL, U.S.A)
  • Year and Date: 2015-10-21
  • Int'l Joint Research
• [Presentation] Hub-centric prefrontal network predicts lesion-effective site for contextual memory in macaques. (2015)
  • Author(s): Osada T, Adachi Y, Miyamoto K, Jimura K, Setsuie R, Watanabe T, Miyashita Y
  • Organizer: Neuroscience 2016
  • Place of Presentation: McCormick Place (Chicago, IL, U.S.A)
  • Year and Date: 2015-10-20
  • Int'l Joint Research
• [Presentation] Dissociable memory formation processes within the macaque medial temporal lobe (2014)
  • Author(s): Miyamoto K, Adachi Y, Osada T, Watanabe T, Setsuie R, Kimura HM, Watanabe T, Miyashita Y
  • Organizer: Neuroscience 2014
  • Place of Presentation: Walter E. Washington Convention Center (Washington, D.C., U.S.A.)
  • Year and Date: 2014-11-19
• [Presentation] Network-level collective effects on the shaping of brain-wide functional architectures: Perspectives from functional MRI in macaque monkeys. in Symposium "From Cell to Organism: Identification, Measurement and Perturbation of Cellular Circuits in vivo" (2014)
  • Author(s): Adachi Y
  • Organizer: 第87回日本生化学大会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2014-10-18
• [Presentation] Dissociable activity patterns in the macaque medial temporal lobe during memory encoding predict subsequent recognition performance (2014)
  • Author(s): Miyamoto K, Adachi Y, Osada T, Watanabe T, Kimura HM, Setsuie R, Watanabe T, Miyashita Y
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-03
• [Presentation] From the tracer-based anatomical network to behavioral impacts on recognition memory task: perspectives from spontaneous BOLD coherence in the macaque cortex. in Morning Workshop “Resting State connectivity: Views From Nonhuman Primates”
  • Author(s): Adachi Y
  • Organizer: The 19th Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Seattle
• [Presentation] Modular structures within macaque memory retrieval network implement functional differentiation during serial probe recognition task.
  • Author(s): Miyamoto K, Osada T, Adachi Y, Matsui T, Kimura HM, Watanabe T, Setsuie R, Miyashita Y.
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] Neural correlates of primacy and recency effects in macaque memory retrieval network.
  • Author(s): Miyamoto K, Osada T, Adachi Y, Matsui T, Kimura HM, Watanabe T, Setsuie R, Miyashita Y.
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego