Investigations of neural correlates in social behavior and the deviations during adolescence
Project/Area Number |
25750405
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Basic / Social brain science
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Research Institution | University of Fukui |
Principal Investigator |
FUJISAWA Takashi 福井大学, 子どものこころの発達研究センター, 特命助教 (90434894)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 思春期 / 青年期 / 衝動性 / 実行機能 / 認知的制御 / 社会的ストレス / 脳イメージング / 性腺ホルモン |
Outline of Final Research Achievements |
This study investigated the neural mechanism underlying development of tolerance for social stress or enhancement of impulsive behavior during adolescence and the deviant behavior. As a result, 1) we developed a model of the tolerance for social stress by conducting large-scale survey, and examined the validity. 2) In a brain imaging study for adolescents with adverse experiences, they have decreased striatal activity during reward processing. The results suggested that dopaminergic dysfunction occurred in the striatum in children and adolescents with adversity, potentially leading to a future risk of psychiatric disorders, such as dependence. 3) In a brain imaging study for adults, we found that individuals with higher tolerance for social stress demonstrated stronger connectivity within executive functional network.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Family based association study of ZNF533, DOCK4 and IMMP2L gene polymorphisms linked to Autism in a Han population in northeastern China.2014
Author(s)
Liang S, Wang X, Zoua M, Wanga H, Zhoua X, Suna C, Xia W, Wu L*, Fujisawa TX, Tomoda A.
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Journal Title
J Zhejiang Univ Sci B
Volume: 15(3)
Issue: 3
Pages: 264-71
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 青年期ASD者における視線計測と血漿オキシトシン濃度の関連2014
Author(s)
升谷泰裕, 岡本悠子, 藤澤隆史, 田仲志保, 新井清義, 浅野みずき, 丁ミンヨン, 石川俊介, 藤岡徹, 石飛信, 松村由紀子, 友田明美, 小坂浩隆
Organizer
第55回日本児童青年精神医学会総会
Place of Presentation
浜松、アクトシティ浜松
Year and Date
2014-10-11
Related Report
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[Presentation] Preliminary fMRI study during the reward task in children and adolescents with Reactive Attachment Disorder.2014
Author(s)
Takiguchi S, Fujisawa TX, Saito DN, Mizushima S, Kumazaki H, Koizumi M, Jung M, Kosaka H, Tomoda A.
Organizer
XXth ISPCAN International Congress
Place of Presentation
Nagoya, Japan, 名古屋国際会議場
Year and Date
2014-09-01
Related Report
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[Presentation] Genetic variants of the estrogen receptor affected the severity of autism spectrum disorders.
Author(s)
Fujisawa TX, Nishitani S, Iwanaga R, Matsuzaki J, Kawasaki C, Tochigi M, Sasaki T, Kato N, Shinohara K.
Organizer
WFSBP Congress
Place of Presentation
Kyoto, Japan, Kyoto International Conference Center
Related Report
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[Presentation] Relationship between gaze fixations and oxytocin levels in adults with autism spectrum disorders: an eye-tracking study.
Author(s)
Inohara K, Fujisawa TX, Masuya Y, Ishitobi M, Asano M, Saito DN, Jung M, Arai S, Matsumura Y, Tomoda A, WadaY, Kosaka H.
Organizer
Fukui2014: The Fifth International Workshop on Biomedical Imaging
Place of Presentation
Fukui, Japan, Yours Hotel Fukui
Related Report
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[Presentation] Assessment of gait asymmetry in children with and without ADHD: Approach using quantitative analysis.
Author(s)
Naruse H, Yatsuga C, Fujisawa TX, Kumazaki H, Mizushima S, Takiguchi S, Aoi T, Kojima M, Koizumi M, Shimada S, Tomoda A.
Organizer
Fukui2014: The Fifth International Workshop on Biomedical Imaging
Place of Presentation
Fukui, Japan, Yours Hotel Fukui
Related Report
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[Presentation] FMRI study of the reward system of pediatric patients with Reactive Attachment Disorder.
Author(s)
Takiguchi S, Fujisawa TX, Saito DN, Yatsuga C, Kumazaki H, Mizushima S, Aoi T, Kojima M, Naruse H, Koizumi M, Jung M, Kosaka H, Tomoda A.
Organizer
Fukui2014: The Fifth International Workshop on Biomedical Imaging
Place of Presentation
Fukui, Japan, Yours Hotel Fukui
Related Report
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[Presentation] Task-based fMRI in ADHD.
Author(s)
Fujisawa TX, Tomoda A.
Organizer
Symposium: ADHD and brain, 2nd Asian Congress on ADHD
Place of Presentation
Tokyo, Japan, Tokyo Medical University Hospital
Related Report
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