Neural basis of cognitive behavioral therapy in patients with social anxiety disorder.

• Project/Area Number: 25780421
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Clinical psychology
• Research Institution: Nagoya City University
• Principal Investigator: KAWAGUCHI Akiko 名古屋市立大学, 大学院医学研究科, 研究員 (20632699)
• Research Collaborator: MORITA TOMOYO ; SADATO NORIHIRO ; OKAMOTO YASUMASA ; SHUTARO NAKAAKI ; KIYOTAKA NEMOTO ; AKECHI TATSUO
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 社交不安症 / 社交不安障害 / fMRI

Outline of Final Research Achievements

This study aimed to investigate the neural basis of social anxiety disorder (SAD) using functional and structured magnetic resonance imaging (MRI). In functional MRI study, we focused on self-reflection for self-face. Patients with SAD showed significantly greater embarrassment for self-face images than healthy controls. We detected anterior rostral medial prefrontal cortex plays a key role in self-reflection. We also reported small insular volume in structured MRI study.

Research Products

• [Journal Article] Insular Volume Reduction in Patients with Social Anxiety Disorder (2016)
  • Author(s): Akiko Kawaguchi1, Kiyotaka Nemoto, Shutaro Nakaaki, Takatsune Kawaguchi, Hirohito Kan5, Nobuyuki Arai, Nao Shiraishi, Nobuhiko Hashimoto, Tatsuo Akechi
  • Journal Title: Front. Psychiatry Volume: ２１ Pages: 3-3
  • DOI: 10.3389/fpsyt.2016.00003
  • NAID: 120007129770
  • Peer Reviewed / Open Access
• [Journal Article] Brain structural abnormalities in behavior therapy-resistant obsessive-compulsive disorder revealed by voxel-based morphometry (2014)
  • Author(s): Hashimoto N, Nakaaki S, Kawaguchi A, Sato J, Kasai H, Nakamae T, Narumoto J,Miyata J, Furukawa TA, Mimura M.
  • Journal Title: Neuropsychiatr Dis Treat Volume: 10 Pages: 1987-1996
  • DOI: 10.2147/ndt.s69652
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 抑うつ不安のオルタナティブ・メディスン：レビュー (2014)
  • Author(s): 川口彰子 渡辺範雄
  • Journal Title: 心身医学 Volume: 54 Pages: 861-866
  • Peer Reviewed
• [Journal Article] 精神障害の長期予後 社交不安障害の長期予後 (2014)
  • Author(s): 川口彰子 渡辺範雄
  • Journal Title: 臨床精神医学 Volume: 43 Pages: 1441-1444
  • Peer Reviewed
• [Journal Article] Hippocampal Volume Increased after Cognitive Behavioral Therapy in a Patient with Social Anxiety Disorder: A Case Report (2014)
  • Author(s): Kawaguchi A, Nakaaki S,Hashimoto N, Ogawa S, Kawaguchi T, Akechi T
  • Journal Title: J Neuropsychiatry Clin Neurosci Volume: 26 Issue: 4 Pages: E4-E5
  • DOI: 10.1176/appi.neuropsych.13090202
  • Peer Reviewed
• [Journal Article] Hippocampal Volume Increased after Cognitive Behavioral Therapy in a Patient with Social Anxiety Disorder: A Case Report (2014)
  • Author(s): Akiko Kawaguchi, Shutaro Nakaaki, Sei Ogawa, Masako Suzuki, Nobuhiko Hashimoto, Takatsune Kawaguchi, Tatsuo Akechi
  • Journal Title: The Journal of Neuropsychiatry and Clinical Neurosciences Volume: －
  • Peer Reviewed
• [Journal Article] 抑うつ・不安のオルタナティブ・メディスン：レビュー (2014)
  • Author(s): 川口彰子、渡辺範雄
  • Journal Title: 心身医学雑誌 Volume: 54
• [Journal Article] A case of schizophrenia accompanied with lissencephaly (2013)
  • Author(s): Akiko Kawaguchi,Shutaro Nakaaki,Takatsune Kawaguchi, Tatsuo Akechi
  • Journal Title: The Journal of Neuropsychiatry and Clinical Neurosciences Volume: 25 Issue: 4 Pages: E17-E18
  • DOI: 10.1176/appi.neuropsych.12090215
  • Peer Reviewed
• [Journal Article] Reduction in white matter before and after the development of delusions of theft in a patient with Alzheimer Disease (2013)
  • Author(s): Nakaaki S, Sato J, Torii K, Kawaguchi T, Kawaguchi A, Narumoto J, Mimura M.
  • Journal Title: The Journal of Neuropsychiatry and Clinical Neurosciences Volume: 25 Issue: 4 Pages: E15-E16
  • DOI: 10.1176/appi.neuropsych.12090214
  • Peer Reviewed
• [Journal Article] Neuroanatomical abnormalities before the onset of different types of delusions in a patient with Alzheimer disease (2013)
  • Author(s): Nakaaki S, Sato J, Torii K, Kawaguchi T, Kawaguchi A, Narumoto J, Mimura M.
  • Journal Title: The Journal of Neuropsychiatry and Clinical Neurosciences Volume: 25 Issue: 3 Pages: E65-E66
  • DOI: 10.1176/appi.neuropsych.12090213
  • Peer Reviewed
• [Journal Article] 精神科領域における最近のMRIの進歩 拡散強調画像（DTI） (2013)
  • Author(s): 川口彰子、仲秋秀太郎
  • Journal Title: 精神科 Volume: ２２ Pages: 353-362
• [Journal Article] 老年精神医学領域における認知行動療法のエビデンス (2013)
  • Author(s): 川口彰子、渡辺範雄
  • Journal Title: 老年精神医学雑誌 Volume: 24 Pages: 479-485
• [Presentation] An introduction of social support and treatment for autism spectrum disorder in Japan (2017)
  • Author(s): 川口彰子
  • Organizer: 第113回日本精神神経学会
  • Place of Presentation: 名古屋国際会議場（愛知県・名古屋市）
  • Year and Date: 2017-06-22
• [Presentation] 社交不安障害における自己意識関連情動に関する機能的MRI（シンポジウム） (2015)
  • Author(s): 川口彰子
  • Organizer: 第7回日本不安症学会
  • Place of Presentation: アステールプラザ（広島県広島市）
  • Year and Date: 2015-02-14 – 2015-02-15
• [Presentation] 社交不安障害患者におけるMRI構造画像研究 (2014)
  • Author(s): 川口彰子 川口毅恒 仲秋秀太郎 白石直 橋本伸彦 菅博人 荒井信行 明智龍男
  • Organizer: 第36回日本生物学的精神医学会
  • Place of Presentation: 奈良県文化会館（奈良県奈良市）
  • Year and Date: 2014-09-29 – 2014-10-01
• [Presentation] 社交不安障害患者における併存症に対する認知行動療法の効果予測因子 (2014)
  • Author(s): 小川成 近藤真前 井野敬子 川口彰子 今井理紗 岡崎純弥 古川壽亮 明智龍男
  • Organizer: 第14回日本認知療法学会
  • Place of Presentation: 大坂国際会議場（大阪府大阪市）
  • Year and Date: 2014-09-12 – 2014-09-13
• [Presentation] 強迫性障害に対するメタ認知療法による介入研究：治療反応者と非反応者の差 (2014)
  • Author(s): 橋本伸彦 仲秋秀太郎 川口彰子
  • Organizer: 第14回日本認知療法学会
  • Place of Presentation: 大坂国際会議場（大阪府大阪市）
  • Year and Date: 2014-09-12 – 2014-09-13
• [Presentation] 認知行動療法終了後のパニック障害患者における併存精神症状と不安感受性 (2014)
  • Author(s): 小川成 近藤真前 井野敬子 川口彰子 今井理紗 岡崎純弥 古川壽亮 明智龍男
  • Organizer: 第110回精神神経学会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2014-06-26 – 2014-06-28
• [Presentation] Policies and Projects for Reforms of Mental Health Services (2014)
  • Author(s): Toshitaka Ii Akiko Kawaguchi1 Wataru.Sano Jun Iwatani Masuo Tanaka Seiju Kobayashi Akihiro Koreki Kumi Aoyama Hironori Kuga
  • Organizer: 第110回精神神経学会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-06-26 – 2014-06-28
• [Presentation] Neural bases basis of embarrassment for of self-face recognition in patients with social anxiety disorders; A functional magnetic resonance imaging study. (2014)
  • Author(s): Akiko Kawaguchi, Tomoyo Morita, Takatsune kawaguchi, Shutaro Nakaaki, Nobuhiko Hashimoto, Tatsuo Akechi
  • Organizer: 29th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Vnacouver Convention Centre(Vancouver, Canada)
  • Year and Date: 2014-06-22 – 2014-06-26
• [Presentation] Structural magnetic resonance imaging study in patients with social anxiety disorder in Japan (2014)
  • Author(s): Takatsune Kawaguchi, Akiko Kawaguchi
  • Organizer: 29th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Vancouvwe Convention Centre(Vancouver, Canada)
  • Year and Date: 2014-06-22 – 2014-06-26
• [Presentation] ヨーロッパ女性の全般性不安障害の事例 (2014)
  • Author(s): 川口彰子
  • Organizer: 第21回多文化間精神医学会学術総会
  • Place of Presentation: 長崎大学医学部 記念講堂（長崎県長崎市）
  • Year and Date: 2014-05-24 – 2014-05-25
• [Presentation] 社交不安障害患者における自己意識関連情動の神経基盤：機能的MRIによる解析 (2014)
  • Author(s): 川口彰子、守田知代、川口毅恒、笠井治昌、菅博人、仲秋秀太郎、岡本泰昌、定藤規弘、明智龍男
  • Organizer: 第6回不安障害学会
  • Place of Presentation: 東京大学（東京）
• [Presentation] Neural bases basis of embarrassment for of self-face recognition in patients with social anxiety disorders: A functional magnetic resonance imaging study (2014)
  • Author(s): Akiko Kawaguchi, Tomoyo Morita, Takatsune kawaguchi, Shutaro Nakaaki, Nobuhiko Hashimoto, Tatsuo Akechi
  • Organizer: 29th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: カナダプレイス（バンクーバー、カナダ）
• [Presentation] Hippocampal volume increased after cognitive behavioral therapy in a patient with social anxiety disorder: A case report (2013)
  • Author(s): Akiko Kawaguchi, Shutaro Nakaaki, Sei Ogawa, Masako Suzuki, Nobuhiko Hashimoto, Takatsune Kawaguchi, Tatsuo Akechi
  • Organizer: The 4th Asian Cognitive Behavior Therapy (CBT) Conference
  • Place of Presentation: 帝京大学（東京）
• [Presentation] 強迫性障害に対するメタ認知療法による介入研究：予備的報告 (2013)
  • Author(s): 橋本伸彦、仲秋秀太郎、川口彰子、工藤由佳、佐藤順子、阪野公一、成本迅、三村將
  • Organizer: 第13回日本認知療法学会
  • Place of Presentation: 帝京大学（東京）
• [Presentation] 認知行動療法によるパニック障害の症状変化が社会機能やQOLに及ぼす影響 (2013)
  • Author(s): 小川成、近藤真前、川口彰子、今井理紗、岡崎純弥、古川壽亮、明智龍男
  • Organizer: 第13回日本認知療法学会
  • Place of Presentation: 帝京大学（東京）
• [Book] 精神疾患の脳画像ケースカンファレンス診断と治療へのアプローチ (2014)
  • Author(s): 仲秋秀太郎 川口彰子 橋本伸彦
  • Total Pages: 10
  • Publisher: 中山書店