Neural mechanisms of cognitive emotion dysregulation in mood disorders

• Project/Area Number: 25780428
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Clinical psychology
• Research Institution: Senshu University
• Principal Investigator: KUNIASATO YOSHIHIKO 専修大学, 人間科学部, 准教授 (30613856)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 臨床心理学 / 気分障害 / 認知的情動制御 / fMRI / 脳機能画像 / 脳構造画像 / 情動制御

Outline of Final Research Achievements

The aim of this study was to examine the neural mechanisms of cognitive emotion regulation of mood disorders. In Study 1, we examined the brain structure associated with ruminative thinking in patients with depression using magnetic resonance imaging. Our results showed that the ruminative thinking positively correlated with the volume of superior temporal gyrus in patients with depression. In Study 2 and 3, we examined the brain activity during cognitive emotion regulation task using functional magnetic resonance imaging. Our results showed the neural mechanisms of cognitive emotion regulation in both positive and negative emotions.

Research Products

• [Journal Article] 診断精度研究の系統的レビューとメタアナリシス (2016)
  • Author(s): 杣取恵太・坂本次郎・時田椋子・鈴木彩夏・国里愛彦
  • Journal Title: 専修人間科学論集 心理学篇 Volume: 6 Pages: 41-58
  • NAID: 120006793212
• [Journal Article] fMRI Study of Social Anxiety during Social Ostracism with and without Emotional Support. (2015)
  • Author(s): Nishiyama Y, Okamoto Y, Kunisato Y, Okada G, Yoshimura S, Kanai Y, Yamamura T, Yoshino A, Jinnin R, Takagaki K, Onoda K, Yamawaki S
  • Journal Title: PLoS One Volume: 10 Issue: 5 Pages: 0127426-0127426
  • DOI: 10.1371/journal.pone.0127426
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 系統的展望とメタアナリシスの必須事項 (2015)
  • Author(s): 国里愛彦
  • Journal Title: 行動療法研究 Volume: 41 Pages: 3-12
  • Peer Reviewed / Open Access
• [Journal Article] Possible involvement of rumination in gray matter abnormalities in persistent symptoms of major depression: An exploratory magnetic resonance imaging voxel-based morphometry study. (2014)
  • Author(s): Machino, A., Kunisato, Y., Matsumoto, T., Yoshimura, S., Ueda, K., Yamawaki, Y., ... & Yamawaki, S.
  • Journal Title: Journal of Affective Disorders Volume: 168 Pages: 229-235
  • DOI: 10.1016/j.jad.2014.06.030
  • Peer Reviewed
• [Journal Article] Distinctive spontaneous regional neural activity in patients with somatoform pain disorder: A preliminary resting-state fMRI study. (2014)
  • Author(s): Atsuo Yoshino, Yasumasa Okamoto , Yoshihiko Kunisato, Shinpei Yoshimura, Ran Jinnin, Yumi Hayashi, Makoto Kobayakawa, Mitsuru Doi, Kyoko Oshita, Ryuji Nakamura, Keisuke Tanaka, Hidehisa Yamashita, Masashi Kawamoto, Shigeto Yamawaki
  • Journal Title: Psychiatry Research: Neuroimaging Volume: 221 Issue: 3 Pages: 246-248
  • DOI: 10.1016/j.pscychresns.2013.12.006
  • Peer Reviewed / Open Access
• [Journal Article] うつ病の脳内メカニズム:Functional MRIを用いた検討 (2014)
  • Author(s): 岡田剛・岡本泰昌・志々田一宏・上田一貴・小野田慶一・国里愛彦・田中沙織・銅谷賢治・山脇成人
  • Journal Title: 精神神経学雑誌 Volume: 116 Pages: 825-831
• [Journal Article] つ病の認知行動療法の脳内作用メカニズムと今後の展開 (2014)
  • Author(s): 国里愛彦・岡本泰昌・吉村晋平・松永美希・岡田剛・吉野敦雄・小野田慶一・上田一貴・鈴木伸一・山脇成人
  • Journal Title: Depression Frontier Volume: 12 Pages: 41-45
• [Journal Article] うつ病における認知行動療法の神経作用メカニズム (2014)
  • Author(s): 国里愛彦・岡本泰昌・吉村晋平・松永美希・岡田剛・吉野敦雄・小野田慶一・上田一貴・鈴木伸一・山脇成人
  • Journal Title: ストレス科学 Volume: 29 Pages: 45-54
• [Journal Article] うつとストレスに対する計算論的アプローチ: 計算論的精神医学入門 (2013)
  • Author(s): 国里愛彦
  • Journal Title: ストレス科学 Volume: 28 Pages: 101-107
• [Journal Article] うつ病と意志決定：計算論的臨床心理学からみたうつ病 (2013)
  • Author(s): 国里愛彦
  • Journal Title: 専修大学社会知性開発研究センター/心理科学研究センター年報 Volume: 2 Pages: 127-145
• [Presentation] 新たなメタ認知課題の作成と妥当性の検討 (2015)
  • Author(s): 杣取恵太・下斗米淳・国里愛彦
  • Organizer: 日本認知・行動療法学会第41回大会
  • Place of Presentation: 仙台
  • Year and Date: 2015-10-02
• [Presentation] 抑うつにおける痛みの将来予測と意思決定：計算論アプローチによる意思決定過程の検討 (2015)
  • Author(s): 坂本次郎・大久保街亜・国里愛彦
  • Organizer: 日本認知・行動療法学会第41回大会
  • Place of Presentation: 仙台
  • Year and Date: 2015-10-02
• [Presentation] 経験サンプリングにおける喫煙に渇望が与える影響：系統的レビューとメタアナリシス (2015)
  • Author(s): 時田椋子・坂本次郎・杣取恵太・澤幸祐・国里愛彦
  • Organizer: 日本認知・行動療法学会第41回大会
  • Place of Presentation: 仙台
  • Year and Date: 2015-10-02
• [Presentation] うつ病の反すうに関する脳画像研究 (2015)
  • Author(s): 国里愛彦
  • Organizer: 日本心理学会第79回大会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-09-22
• [Presentation] Depression and Intertemporal Choice of Pain: Maximum Likelihood Estimation vs. Hierarchical Bayesian Analysis. (2015)
  • Author(s): Sakamoto, J., Somatori, K., Okubo, M., & Kunisato, Y.
  • Organizer: The 48th Annual Meeting of the Society for Mathematical Psychology
  • Place of Presentation: Newport Beach, California, USA.
  • Year and Date: 2015-07-17
  • Int'l Joint Research
• [Presentation] What is a true measure for meta-cognition?: A Bayesian cognitive modeling approach. (2015)
  • Author(s): Somatori, K., Sakamoto, J., Shimotomai, A., & Kunisato, Y.
  • Organizer: The 48th Annual Meeting of the Society for Mathematical Psychology
  • Place of Presentation: Newport Beach, California, USA.
  • Year and Date: 2015-07-17
  • Int'l Joint Research
• [Presentation] 抑うつと強化感受性・他者依存性との関連 (2014)
  • Author(s): 時田椋子・国里愛彦・松永美希
  • Organizer: 日本認知・行動療法学会第40回大会
  • Place of Presentation: 富山
  • Year and Date: 2014-11-03
• [Presentation] 解釈バイアスと否定的・肯定的な将来予期の関連 (2014)
  • Author(s): 坂本次郎・国里愛彦・田中信利
  • Organizer: 日本認知・行動療法学会第40回大会
  • Place of Presentation: 富山
  • Year and Date: 2014-11-03
• [Presentation] 自己愛パーソナリティの誇大特性と過敏特性が非行に与える影響－共感性との関連－ (2014)
  • Author(s): 杣取恵太・国里愛彦・村松 励
  • Organizer: 日本認知・行動療法学会第40回大会
  • Place of Presentation: 富山
  • Year and Date: 2014-11-02
• [Presentation] 介入研究の質のアセスメント：GRADEシステム (2014)
  • Author(s): 国里愛彦
  • Organizer: 日本認知・行動療法学会第40回大会
  • Place of Presentation: 富山
  • Year and Date: 2014-11-02
• [Presentation] Dispositional Envy ScaleおよびEpisodic Envy Scaleの日本語版作成と信頼性・妥当性の検討 (2014)
  • Author(s): 鈴木彩夏・国里愛彦・下斗米 淳
  • Organizer: 日本心理学会第78回大会
  • Place of Presentation: 京都
  • Year and Date: 2014-09-11
• [Presentation] The Volume of Right Superior Temporal Gyrus Mediated the Affect of Rumination to Treatment Response to CBT in Patients with Depression (2014)
  • Author(s): Kunisato, Y., Okamoto Y., Yoshimura S., Ueda K., Matsunaga M., Okada G., Nishiyama Y., Katsuragawa T., Suzuki S., Yamawaki S.
  • Organizer: The European Association for Behavioural and Cognitive Therapies
  • Place of Presentation: Hague, Netherlands
  • Year and Date: 2014-09-10 – 2014-09-13
• [Presentation] Cognitive and behavioral determinats of sick-leave duration and relapses in patients with depression. (2014)
  • Author(s): Suzuki, S., Son, S., Yada, S., Shimizu, K., Kunisato, Y., Suyama, H., Ogawa, Y., Takei, Y., Sasaki, M., Ito, D., Koseki, S., Koseki, M., & Shirai, M.
  • Organizer: 28th International Congress of Applied Psychology
  • Place of Presentation: Paris, French
  • Year and Date: 2014-07-08 – 2014-07-13
• [Presentation] うつ病に対する認知行動療法の神経基盤 (2013)
  • Author(s): 国里愛彦
  • Organizer: 日本心理学会第77回大会
  • Place of Presentation: 札幌
• [Presentation] 臨床研究に繋がるアナログ研究 (2013)
  • Author(s): 国里愛彦
  • Organizer: 日本心理学会第77回大会
  • Place of Presentation: 札幌
• [Presentation] うつ病と認知行動療法の作用機序に関する認知神経科学研究 (2013)
  • Author(s): 国里愛彦
  • Organizer: 第29回日本ストレス学会学術総会
  • Place of Presentation: 徳島
  • Invited