| Project/Area Number |
25780443
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental psychology
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| Research Institution | Tokyo University of Social Welfare |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 注意欠陥多動障害 / 認知機能 |
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| Outline of Final Research Achievements |
We investigated the cognitive function and neuronal morphological characteristics of major histocompatibility complex (MHC) class I deficit mice as an animal model of attention deficit/ hyperactive disorder. MHC class I deficit mice showed motor impulsivity and inattention. However there are no differences between wild-type mice and MHC class I deficit mice in acquisition of spatial learning and reversal learning tasks, and cognitive impulsivity. Neuronal characteristics were analyzed using Golgi-Cox staining. In the nucleus accumbens, there are no differences between wild-type mice and MHC class I deficit mice in dendrite length and number of branches. In the striatum, the percentage of immature spine was greater in MHC class I deficit mice than wild-type mice. In the cingulate cortex area1, MHC class I deficit mice had longer dendrite, and also larger number of branches compared to wild-type mice.
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