Brain regions responsible for processing and storage of meaningful visual information in older adults
| Project/Area Number |
25780456
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental psychology
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
KUNIMI Mitsunobu 独立行政法人国立長寿医療研究センター, 長寿医療工学研究部, 研究員 (70460384)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | fMRI / 加齢 / 記憶 / 視覚情報 |
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| Outline of Final Research Achievements |
The BOLD signals produced in the regions responsible for working memory (WM) are augmented in a task load-dependent manner and are also affected by aging. The purpose of this study is 1) to investigate the effect of meaningfulness of visual information for WM in older adults, 2) to examine whether the WM load-dependent BOLD response gradient (WBG) can be used to assess age-related effects on WM and 3) to identify the optimal brain regions for objectively evaluating the extent of such changes. An analysis of the subjects’ imaging data detected an interactive effect between age and WM load on the WBG, which was derived from greater recruitment of neuronal resources and a reduced WM capacity in older adults. In addition, it was found that the age-related differences in the WBG were particularly marked in the bilateral frontal and the left parietal regions. Focusing on these areas might be useful for detecting the effects of aging on WM in the clinical setting.
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Report
(3 results)
Research Products
(10 results)
