Development of pulmonary surfactant preparations incorprated by fluorinated materials
| Project/Area Number |
25790020
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nanomaterials chemistry
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| Research Institution | Nagasaki International University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHIBATA Osamu 長崎国際大学, 薬学部薬学科, 教授 (10117129)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | ナノ機能材料 / ナノ医薬 / 肺サーファクタント / 複合材料 |
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| Outline of Final Research Achievements |
Our objective is to develop cheap, safe, and effective artificial pulmonary surfactant preparations. Our attention was here paid on "cheapness" for the production cost of the preparations. The main component of the natural pulmonary surfactants is dipalmitoylphosphatidylcholine (DPPC) and thus we try to substitute with phospholipids derived from an egg yolk and a soybean. First, we made lots of artificial preparations model peptide (Hel 13-5) and their interfactial properties have been investigated thoroughly. As a result, some preparations were possible to be produced at the cheaper cost than Surfacten and also they indicated the effect at the same level as Surfacten. We intend to examine the pulmonary surfactactant preparations by incorporation of fluorinated componds which have high oxygen dissolution ability and very chemical stablization to get the further efficacy.
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Report
(3 results)
Research Products
(97 results)
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[Journal Article] Impairing effect of fibrinogen on the mono-/bi-layer form of bovine lung surfactant2014
Author(s)
Ravi Devraj, Kaushik Nag, Prasant Nahak, Kausik Manna, Mauricia Fritzen-Garcia, David W. Thompson, Kimiko Makino, Hiroyuki Ohshima, Hiromichi Nakahara, Osamu Shibata, Amiya Kumar Panda
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Journal Title
Colloid Polym. Sci.
Volume: 292
Issue: 11
Pages: 2765-2774
DOI
Related Report
Peer Reviewed
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[Journal Article] Effect of Serum, Cholesterol and Low Density Lipoprotein on the Functionality and Structure of Lung Surfactant Films2014
Author(s)
Prasant Nahak, Kaushik Nag, Ashley Hillier, Ravi Devraj, David W. Thompson, Kausik Manna, Kimiko Makino, Hiroyuki Ohshima, Hiromichi Nakahara, Osamu Shibata, Amiya Kumar Panda
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Journal Title
Journal of Oleo Science
Volume: 63
Issue: 12
Pages: 1333-1349
DOI
NAID
ISSN
1345-8957, 1347-3352
Related Report
Peer Reviewed / Open Access
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