| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
In this study, we developed a nano- and microfluidic chip in order to perform the imaging of single circular DNA molecules directly in real time for dynamics studies based on biochemical reactions, the surrounding environment effect and thermodynamics. To observe the single circular DNA molecules directly ,we success the technique for imaging and measuring in real time with developing nano- and microfluidic chip. By using the chip, for instance, the condensation of single circular DNA molecules and single-strand-damage of the DNA in real time were able to measure and image in high sensitivity.
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