Development of high resolution PET detector for cell level imaging

• Project/Area Number: 25790073
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General applied physics
• Research Institution: The University of Tokyo
• Principal Investigator: SHIMAZOE Kenji 東京大学, 工学(系)研究科(研究院), 助教 (70589340)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: ピクセル検出器 / SiPM / MPPC / digital SiPM / PET / ピクセル型検出器

Outline of Final Research Achievements

GAGG crystal arrays with the pitch of 500 micro meter and 200 micro meter are fabricated for the imaging of cells whose size is approximately from tens of micro meters to hundreds of micro meters. The position discrimination is confirmed with the crystal array coupled to digital silicon photomultiplier (SiPM). The position discrimination and energy histgram is acquired with the crystal array coupled to TSV (Through Silicon Via) type MPPC (Multi Pixel Photon Counter) using charge division readout system. This indicate the possiblity of the order of few hundreds micro meters spatial resolution. The prototype of PET scanner based on digital SiPM is also designed and fabricated.

Research Products

• [Journal Article] A PET detector prototype based on digital SiPMs and GAGG scintillators. (2015)
  • Author(s): Florian R Schneider, Kenji Shimazoe, Ian Somlai-Schweiger and Sibylle I Ziegler
  • Journal Title: Physics in medicine and biology Volume: 60(4) Issue: 4 Pages: 1664-79
  • DOI: 10.1088/0031-9155/60/4/1667
  • Peer Reviewed
• [Journal Article] Development of a prototype of time-over-threshold based small animal PET scanner (2014)
  • Author(s): K. Shimazoe, H. Takahashi, K. Kamada, A. Yoshikawa, K. Kumagai, J. Kataoka, S. Itoh, H. Sato, Y. Usuki
  • Journal Title: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment Volume: 753 Pages: 84-90
  • DOI: 10.1016/j.nima.2014.04.008
  • Peer Reviewed
• [Journal Article] Recent Developments in Pixelated Gamma Ray Detector and Imaging System (2014)
  • Author(s): Kenji Shimazoe
  • Journal Title: Journal of the Vacuum Society of Japan Volume: 57 Issue: 2 Pages: 66-70
  • DOI: 10.3131/jvsj2.57.66
  • NAID: 130003394498
  • ISSN: 1882-2398, 1882-4749
  • Peer Reviewed
• [Presentation] Development of high-resolution gamma detector using sub-mm GAGG crystal coupled to MPPC array (2015)
  • Author(s): Alina Lipovec, Kenji Shimazoe, Hiroyuki Takahashi
  • Organizer: International Workshop on Radiation Imaging Detectors 2015
  • Place of Presentation: Hamburg, Germany
  • Year and Date: 2015-06-28 – 2015-07-02
• [Presentation] Development of SiPM DOI detector for high resolution PET system (2014)
  • Author(s): Alina Lipovec , Kenji Shimazoe, Hiroyuki Takahashi
  • Organizer: 応用物理学会
  • Place of Presentation: 北海道大学、北海道
  • Year and Date: 2014-09-17 – 2014-09-20
• [Presentation] デジタルシリコンフォトマル及びその応用 (2013)
  • Author(s): 島添健次，織田忠, 高橋浩之, Florian Scheneider，Ian Somlai，Sibylle Ziegler
  • Organizer: 応用物理学会
  • Place of Presentation: 京都市・同志社大学
• [Presentation] 小型ピンホールガンマカメラの開発 (2013)
  • Author(s): 島添健次，高橋浩之, 佐藤浩樹，薄善行 ，鎌田圭 , 吉 川彰
  • Organizer: 応用物理学会
  • Place of Presentation: 京都市・同志社大学