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A C-11 molecule production/separation system for C-11 ion production

Research Project

Project/Area Number 25790090
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Quantum beam science
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

Katagiri Ken  国立研究開発法人放射線医学総合研究所, 重粒子医科学センター, 研究員 (90510868)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2014: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
KeywordsISOL / 重粒子線がん治療 / RIビーム / イオン源 / 加速器 / 不安定核ビーム / 真空技術 / 真空
Outline of Final Research Achievements

A C-11 molecular production/separation system (CMPS) has been developed for heavy-ion cancer therapy and simultaneous positron emission tomography imaging using radioactive C-11 ion beams. In the CMPS, 11CH4 molecules are produced by proton irradiation and separated from residual air impurities and impurities produced during the irradiation. The CMPS includes two cryogenic traps to selectively separate specific molecules from impurities by using vapor pressure differences among the molecular species. We investigated the separation of CH4 molecules from impurities, which will be present as residual gases and are expected to be difficult to separate because the vapor pressure of air molecules is close to that of CH4. We determined the collection/separation efficiencies of the CMPS for various amounts of air impurities and found desirable operating conditions for the CMPS.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (12 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Acknowledgement Compliant: 3 results,  Open Access: 2 results) Presentation (6 results) (of which Int'l Joint Research: 3 results)

  • [Int'l Joint Research] JINR(ロシア連邦)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] A singly charged ion source for radioactive 11C ion acceleration2016

    • Author(s)
      K. Katagiri, A. Noda, K. Nagatsu, M. Nakao, S. Hojo, M. Muramatsu, K. Suzuki, T. Wakui, and K. Noda
    • Journal Title

      Rev. Sci. Instrum.

      Volume: 87 Issue: 2

    • DOI

      10.1063/1.4935899

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cryogenic molecular separation system for radioactive 11C ion acceleration2015

    • Author(s)
      K. Katagiri, A. Noda, K. Suzuki, K. Nagatsu, A. Yu. Boytsov, D. E. Donets, E. D. Donets, E. E. Donets, A. Yu. Ramzdorf, M. Nakao, S. Hojo, T. Wakui, and K. Noda
    • Journal Title

      Rev. Sci. Instrum.

      Volume: 86 Issue: 12

    • DOI

      10.1063/1.4937593

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] ISOL ION SOURCE FOR HEAVY ION CANCER RADIOTHERAPY2015

    • Author(s)
      Ken Katagiri, Akira Noda, Masao Nakao, Hojo Satoru, Kotaro Nagatsu, Kazutoshi Suzuki, Takashi Wakui, Koji Noda
    • Journal Title

      Proceedings of Particle Accelerator Society

      Volume: Tsuruga, Japan Pages: 75-75

    • Related Report
      2015 Annual Research Report
    • Open Access / Acknowledgement Compliant
  • [Journal Article] NIRS サイクロトロン・RI 生成用ビームポートのためのビーム輸送ラインの設計2014

    • Author(s)
      片桐 健
    • Journal Title

      Proceedings of the 11th Annual Meeting of Particle Accelerator Society of Japan

      Volume: 2014, Aomori Pages: 1360-1362

    • Related Report
      2014 Research-status Report
    • Open Access
  • [Journal Article] 11CH4-molecule production using a NaBH4 target for 11C-ion acceleration2014

    • Author(s)
      Ken Katagiri, Koutaro Nagatsu, Katsuyuki Minegishi, Satoru Hojo, Masayuki Muramatsu, Kazutoshi Suzuki, Toshihiro Honma, Atsushi Kitagawa, Akira Noda, Koji
    • Journal Title

      Rev. Sci. Instrum.

      Volume: 85 Issue: 2

    • DOI

      10.1063/1.4826605

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Radioactive C-11 ion production/acceleration for heavy-ion cancer therapy2016

    • Author(s)
      K. Katagiri, A. Noda, K. Nagatsu, K. Suzuki,T. Wakui, K. Noda
    • Organizer
      [49]7th Asian Forum for Accelerators and Detectors (AFAD2016)
    • Place of Presentation
      Uji Campus, Kyoto University, Kyoto, Japan
    • Year and Date
      2016-02-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Research and developments toward radioactive 11C ion acceleration2015

    • Author(s)
      K. Katagiri, A. Noda, K. Nagatsu, S. Hojo, M. Nakao, K. Suzuki, M. Muramatsu, T. Hattori, T. Wakui, K. Noda.
    • Organizer
      13th International Conference on Heavy Ion Accelerator Technology (HIAT 2015)
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 重粒子線治療のためのISOLシステムに用いる1価イオン源の開発2015

    • Author(s)
      片桐 健,他
    • Organizer
      日本加速器学会年会
    • Place of Presentation
      敦賀,福井
    • Year and Date
      2015-08-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 10/11C イオン生成 · 加速のための 10/11C 分子生成 · 分離システムの開発2014

    • Author(s)
      片桐 健
    • Organizer
      公益社団法人 応用物理学会
    • Place of Presentation
      北海道大学
    • Year and Date
      2014-09-18
    • Related Report
      2014 Research-status Report
  • [Presentation] NIRS サイクロトロン・RI 生成用ビームポートのためのビーム輸送ラインの設計2014

    • Author(s)
      片桐 健
    • Organizer
      日本加速器学会
    • Place of Presentation
      青森
    • Year and Date
      2014-08-10
    • Related Report
      2014 Research-status Report
  • [Presentation] 11CH4-molecule production using a NaBH4 target for 11C-ion acceleration2013

    • Author(s)
      Ken Katagiri
    • Organizer
      [36] The 15th International Conference on Ion Sources (ICIS’13)
    • Place of Presentation
      千葉
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2022-01-31  

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