| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
The investigation of autonomous molecular machines attracts much interest not only in terms of nonequilibrium statistical mechanics but also quantitative biology. In this study, I focus on the role of autonomous information processing in molecular machines, and constructed a general thermodynamic theory of autonomous information processing. I have derived a generalized fluctuation theorem including information flow, which leads to the second law of thermodynamics with autonomous information processing. This has revealed the fundamental role of information flow in nonequilibrium statistical mechanics. Furthermore, I have applied the general theory to biochemical signal transduction, and found the relationship between information flow and robustness of adaptation of bacterial chemotaxis.
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