Vesicle dynamics induced by chemical stimuli
| Project/Area Number |
25800233
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological physics/Chemical physics/Soft matter physics
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| Research Institution | Tohoku University |
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Principal Investigator |
Sakuma Yuka 東北大学, 理学研究科, 助教 (40630801)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ベシクル / 化学刺激 / 膜変形 / 分子形状 / 国際情報交換 / フランス |
|---|
| Outline of Final Research Achievements |
To understand the response of molecular assemblies against chemical stimuli is essential for approaching cell dynamics, such as cell deformation and division, from soft matter physics point of view. In this study, I focused on the vesicle dynamics relevant to cell functions induced by chemical stimuli, especially pore formation that plays an important role in membrane traffic. I succeed to reproduce pore formation on the vesicle by injecting hydroxide ions to phospholipid vesicles containing anionic lipids. The interaction between anionic lipid and hydroxide ion decreases cross section area of lipids, which produces the surface tension and then pore formation. This chemical control of pore formation is a first step to reveal biological function non-equilibrium soft matter physics point of view.
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Report
(5 results)
Research Products
(33 results)
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[Presentation] MECHANISM OF SELF-REPRODUCING VESICLES2017
Author(s)
Takehiro Jimbo, Yuka Sakuma, Masayuki Imai, Naohito Urakami, Primoz Ziherl
Organizer
Biophysical Society 61st Annual Meeting
Place of Presentation
New Orleans, U.S.A.
Year and Date
2017-02-11
Related Report
Int'l Joint Research
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[Presentation] A Key for self-reproduction of vesicles2015
Author(s)
Takehiro Jimbo, Yuka Sakuma, Primoz Ziherl and Masayuki Imai
Organizer
International Symposium on Fluctuation and Structure out of Equilibrium 2015
Place of Presentation
Shiran-kaikan (Kyoto, Japan)
Year and Date
2015-08-20
Related Report
Int'l Joint Research
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