| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
To understand the response of molecular assemblies against chemical stimuli is essential for approaching cell dynamics, such as cell deformation and division, from soft matter physics point of view. In this study, I focused on the vesicle dynamics relevant to cell functions induced by chemical stimuli, especially pore formation that plays an important role in membrane traffic. I succeed to reproduce pore formation on the vesicle by injecting hydroxide ions to phospholipid vesicles containing anionic lipids. The interaction between anionic lipid and hydroxide ion decreases cross section area of lipids, which produces the surface tension and then pore formation. This chemical control of pore formation is a first step to reveal biological function non-equilibrium soft matter physics point of view.
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