Creation of crystalline nanocavities based on peptide folding
| Project/Area Number |
25810046
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional solid state chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SAWADA Tomohisa 東京大学, 工学(系)研究科(研究院), 助教 (70625467)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 自己組織化 / 結晶材料 / ペプチド / 配位結合 / 分子認識 / ナノ空間 / フォールディング / 単結晶 |
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| Outline of Final Research Achievements |
In this work, a new artificial peptide-based nanomaterial was created by the strategy of coordination-driven self-assembly with concomitant folding and assembly processes. A tripeptide with coordinating groups at both termini was designed and successfully complexed with silver(I) ion to give a crystalline porous material. The nanochannel of this material was composed of polyproline II helix of the peptide ligand and its diameter reached more than 2-nm-size. Furthermore, unique molecular recognition properties of this new material were also revealed.
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Report
(3 results)
Research Products
(18 results)
