Catalyst Design Based on a Multi-Point Immobilization Strategy for Practical Organic Synthesis with Non-Platinum Group Metals
| Project/Area Number |
25810056
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
Iwai Tomohiro 北海道大学, 理学(系)研究科(研究院), 助教 (30610729)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 不均一系触媒 / 非白金属元素 / ホスフィン / 遷移金属触媒 / クロスカップリング / ポリスチレン / シリカゲル / ビスホスフィン / ニッケル / アミノ化 / C-H活性化 / ピバル酸アリール / 塩化アリール / ホスフィン配位子 / 固相担持 / C－H活性化 / パラジウム / ロジウム |
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| Outline of Final Research Achievements |
The researcher worked on the development of highly active catalysts for practical organic synthesis with non-platinum group metals on the basis of an independently developed multi-point immobilization strategy. A newly prepared polystyrene-cross-linking bisphosphine PS-DPPBz containing a 1,2-bis(diphenylphosphino)benzene core was found to be an effective ligand for the Ni-catalyzed amination of aryl chlorides with N-alkyl-substituted primary amines, the Ni-catalyzed C-H/C-O coupling between 1,3-azoles and aryl pivalates, and the Co-catalyzed alkene hydroboration. During this study, it was found that solid-supported monophosphines with mono-P-ligating properties enabled the heteroatom-directed Ir-catalyzed C(sp3)-H borylation and the Pd-catalyzed cross-coupling of aryl chlorides.
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Report
(4 results)
Research Products
(49 results)
