| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
With the aim of developing a novel nucleophilic catalyst possessing both of a stereogenic center and a hydrogen-bond donor cite at the position adjacent to the nucleophilic cite, a 1,2,4-triazadiphosphole catalyst was designed and investigated. As a result, we achieved the short-step construction of the triazadiphosphole framework. The catalytic activity of the triazadiphosphole thus synthesized was evaluated, and the compound was found to function as an organobase although the application as a nucleophilic catalystwas not succeeded. After the revision of catalyst structure, a novel bifunctional chiral strong organobase catalyst, which has a quaternary ammonium moiety as a hydrogen-bond donor, was designed and synthesized. The application of the catalyst to some reactions suggested that the quaternary ammonium moiety could effectively serve as a hydrogen-bond donor and involve the stereocontrol of the reactions.
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