| Project/Area Number |
25810060
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
YUKI Naganawa 名古屋大学, 工学(系)研究科(研究院), 助教 (00613233)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 有機合成 / 不斉反応 / 遷移金属 / ロジウム / イリジウム / ケイ素 / 触媒 / 触媒的不斉合成 / フェナントロリン / 還元 |
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| Outline of Final Research Achievements |
Recently, catalytic asymmetric constructions of chiral silicon centers have been of great interest considering their unique chemical and physical properties. In this context, we demonstrated Rh-catalyzed enantioselective desymmetrizing intramolecular hydrosilylation of symmetrically disubstituted hydrosilanes. The original axially chiral phenanthroline ligand was found to work as an effective chiral catalyst for this transformation. A chiral silicon-stereogenic center is one of the chiral motifs gaining much attention in asymmetric syntheses and the present protocol provides cyclic five-membered organosilanes with a chiral silicon center with high enantioselectivity. Next, we are interested in application of Ir-catalyzed direct C-H silylation to the construction of chiral silicon center. Also for this transformation, the chiral phenanthrolines worked as effective ligands to give the desired products with moderate enantioselectivity.
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