| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
A regioselective and enantiospecific cross-coupling reaction of N-tosyl-2-arylaziridines with arylboronic acids to give enantiopure 2-aryl-beta-phenethylamine derivatives in high yields has been realized under the effect of a catalytic amount of Pd complex bearing a NHC ligand. Under the similar reaction conditions, 2-carboxy ester-substituted aziridines underwent a regioselective cross-coupling to give non-naturally occurring beta-amino acid derivatives in moderate yields. Furthermore, a Pd-catalyzed regioselective ring-opening borylation of 2-arylaziridines has been found.
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