| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The amide bond is a ubiquitous and thermodynamically stable due to amide resonance where the lone pair of electrons on the nitrogen is delocalized into the carbonyl. Although amide-directed C-H bond functionalization is an attractive topic of interest, cleavage of the amide bond is difficult owing to the inert nature of amides and thus its application is limited. Under such background, we developed esterification of unactivated amides catalyzed by combined catalytic system of scandium triflate and boron compounds as well as manganese complex bearing N-bidentate ligand. In addition, Ru-catalyzed hydrogenation of amides was efficiently promoted by the addition of catalytic amount of zinc salt.
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