Development of amide transformation by catalytic system inhibiting amide resonance
| Project/Area Number |
25810062
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
Kita Yusuke 大阪大学, 基礎工学研究科, 助教 (40593489)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | アミド結合切断 / エステル化 / 水素化 / アミド変換 / 加アルコール分解 |
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| Outline of Final Research Achievements |
The amide bond is a ubiquitous and thermodynamically stable due to amide resonance where the lone pair of electrons on the nitrogen is delocalized into the carbonyl. Although amide-directed C-H bond functionalization is an attractive topic of interest, cleavage of the amide bond is difficult owing to the inert nature of amides and thus its application is limited. Under such background, we developed esterification of unactivated amides catalyzed by combined catalytic system of scandium triflate and boron compounds as well as manganese complex bearing N-bidentate ligand. In addition, Ru-catalyzed hydrogenation of amides was efficiently promoted by the addition of catalytic amount of zinc salt.
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Report
(4 results)
Research Products
(11 results)
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[Presentation] Manganese-catalyzed Esterification of Amides2015
Author(s)
Yusuke Kita, Yuji Nishii, Shoko Akiyama, Kazushi Mashima
Organizer
The 13th International Kyoto Conference on New Aspects of Organic Chemistry
Place of Presentation
リーガロイヤルホテル京都（京都府京都市）
Year and Date
2015-11-09
Related Report
Int'l Joint Research
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