| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
We have developed a method of real-time measuring cathepsin B activity for degrading collagen IV, which is a fundamental component of the extra cellular matorix proteins. This method has indicated that collagen IV was degraded by exopeptidase and endopeptidase activity. In addition, an evaluation method of inihibitory activity for digesting collagen IV has been developed. In order to develop an imaging method for degradation of collagen IV in local area formed between cell and collagen IV, we have made a surface plasmon resonance imaging apparatus.
|
