Photoinduced charge separation molecules for control on membrane protein functions
| Project/Area Number |
25810098
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bio-related chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
TAKANO Yuta 京都大学, 物質ー細胞統合システム拠点, 助教 (60580115)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 光誘起電荷分離分子 / 脱分極 / フラーレン / 金属内包フラーレン / ポルフィリン / 光線療法 / ＰＣ１２細胞 / PC１２細胞 |
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| Outline of Final Research Achievements |
Cell membrane potential plays a crucial role in cellular functionｓ in various cells such as nerve cells. Therefore, artificial control on the membrane potential is promising technology for cellular engineering and medical applications. For the control, we have studied on organic molecules which can generate charge separated state by irradiation in cellular environment. As a fruit, we found a molecular system which display efficient charge separation (quantum yield = 41%). In a series of study revealed that the molecules can induce depolarization in membrane of PC12 and rat hippocampal neurons. In addition, the degrees parallel the charge separation efficiency.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Unprecedented Chemical Reactivity of a Paramagnetic Endohedral Metallofullerene La@Cs-C82 that Leads Hydrogen Addition in the 1,3-Dipolar Cycloaddition Reaction2014
Author(s)
Y. Takano, Z. Slanina, J. Mateos, T. Tsuchiya, H. Kurihara, F. Uhlik, M.A. Herranz, N. Martin, S. Nagase, and T. Akasaka
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Journal Title
J. Am. Chem. Soc.
Volume: 136
Issue: 50
Pages: 17537-17546
DOI
Related Report
Peer Reviewed
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