| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Outline of Final Research Achievements |
In glycosphingolipid chemistry, an increasing interest has been placed on carbohydrate-carbohydrate interactions (CCIs) and it is now recognized that CCIs act as main driving forces to induce various cellular recognition events. In spite of importance of CCIs, not only fluidic nature but also fluctuations of glycosphingolipid levels on the cell surfaces make it quite difficult to investigate CCIs in a detailed manner. Simple and well-designed model systems are, therefore, highly required in this research field.
In this project, we synthesized glycosylated 1,10-bupyridines and then, used them for complexation with ferrous ion to construct the corresponding tris-bipyridine ferrous complexes having multivalent glycosylated clusters. The resultant glycoclusters showed circular dichrosm (CD) spectra characteristic for Δ-isomers. Their CD spectral changes on additions of various alkaline/alkaline-earth metal ions were monitored through CD spectral analyses.
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