Development of Hydrogen Cyanide and Hydrogen Sulfide Receptors

• Project/Area Number: 25810106
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Bio-related chemistry
• Research Institution: Kyushu University
• Principal Investigator: WATANABE Kenji 九州大学, 薬学研究科(研究院), 特任助教 (90631937)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ポルフィリン / シクロデキストリン / シアン化水素 / 硫化水素 / シアン化物イオン / 鉄ポルフィリン / 包接錯体

Outline of Final Research Achievements

A supramolecule (met-hemoCD3) was prepared by including a water-soluble porphinato iron(III) in a capsule of a O-methylated cyclodextrin dimer (Py3OCD), which was synthesized in only two steps. Ferric met-hemoCD3 showed functions similar to methemoglobin and also functioned as an antidote for cyanide poisoning. We then studied the reaction between hydrosulfide (SH-) and met-hemoCD3. Met-hemoCD3 formed a stable (SH-)-met-hemoCD3 complex in oxygen-free neutral aqueous solution, while reversible ligand exchange between (SH-)-met-hemoCD3 (Fe(III)) and O2-hemoCD3 (Fe(II)) occurred under O2 atmosphere.

Research Products

• [Journal Article] Reaction between a haemoglobin model compound and hydrosulphide in aqueous solution (2015)
  • Author(s): Kenji Watanabe, Toshikane Suzuki, Hiroaki Kitagishi, Koji Kano
  • Journal Title: Chemical Communications Volume: 51 Issue: 19 Pages: 4059-4061
  • DOI: 10.1039/c5cc00057b
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Supramolecular iron porphyrin/Cyclodextrin dimer complex that mimics the functions of hemoglobin and methhemoglobin (2013)
  • Author(s): Watanabe K, Kitagishi K, Kano K
  • Journal Title: Angew Chem Int Ed Volume: 52 Issue: 27 Pages: 6894-6897
  • DOI: 10.1002/anie.201302470
  • Peer Reviewed
• [Journal Article] Supramolecular ferric porphyrins and a cyclodextrin dimer as an antidote for cyanide poisoning (2013)
  • Author(s): Yamagiwa T, Kawaguchi AT, Saito T, INoue S, Morita S, Watanabe K, Kitagishi H, Koji K, Inokuchi S.
  • Journal Title: Human and experimental toxicology Volume: Aug5 Issue: 4 Pages: 1-9
  • DOI: 10.1177/0960327113499041
  • Peer Reviewed
• [Presentation] 水溶性鉄ポルフィリン超分子によるシアン化物イオンの捕捉 (2014)
  • Author(s): 渡辺賢司、北岸宏亮、大嶋孝志、加納航治
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本
• [Presentation] Binding of Inorganic Anions to Supramolecular Complexes of an Anionic Porphyrin and Per-O-Methylated b-Cyclodextrins (2013)
  • Author(s): Kano, K.; Kitagishi, H.; Watanabe, K.
  • Organizer: The 7th Asian Cyclodextrin Conference
  • Place of Presentation: Bangkok, Thailand
  • Invited