Development of Hydrogen Cyanide and Hydrogen Sulfide Receptors
| Project/Area Number |
25810106
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bio-related chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
WATANABE Kenji 九州大学, 薬学研究科(研究院), 特任助教 (90631937)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ポルフィリン / シクロデキストリン / シアン化水素 / 硫化水素 / シアン化物イオン / 鉄ポルフィリン / 包接錯体 |
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| Outline of Final Research Achievements |
A supramolecule (met-hemoCD3) was prepared by including a water-soluble porphinato iron(III) in a capsule of a O-methylated cyclodextrin dimer (Py3OCD), which was synthesized in only two steps. Ferric met-hemoCD3 showed functions similar to methemoglobin and also functioned as an antidote for cyanide poisoning. We then studied the reaction between hydrosulfide (SH-) and met-hemoCD3. Met-hemoCD3 formed a stable (SH-)-met-hemoCD3 complex in oxygen-free neutral aqueous solution, while reversible ligand exchange between (SH-)-met-hemoCD3 (Fe(III)) and O2-hemoCD3 (Fe(II)) occurred under O2 atmosphere.
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Report
(3 results)
Research Products
(5 results)
