Design of biomaterial surface for improving protein adsorption capacity

• Project/Area Number: 25820354
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Structural/Functional materials
• Research Institution: Nagoya Institute of Technology
• Principal Investigator: MAEDA Hirotaka 名古屋工業大学, 工学(系)研究科(研究院), 准教授 (20431538)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 骨修復材料 / ケイ酸カルシウム / リン酸カルシウムクラスター / 水熱合成 / タンパク質吸着 / タンパク質 / 水熱反応

Outline of Final Research Achievements

The possibility of incorporating calcium phsophate clusters into tobemorite was examined to prepare new types of biomaterials with high performance. The spectroscopic and simulation results indicated that the clusters were incorporated into the nano-sized space of tobermorite structure by a hydrothermal reaction. The existence of the clusters enhanced the biocompatibility.

Research Products

• [Journal Article] Tuning of calcium silicate ceramics for environment-friendly material applications (2014)
  • Author(s): Hirotaka Maeda
  • Journal Title: Journal of the Ceramic Society of Japan Volume: 122 Issue: 1430 Pages: 858-862
  • DOI: 10.2109/jcersj2.122.858
  • NAID: 130004951037
  • ISSN: 1348-6535, 1882-0743
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Calcium phosphate cement with silicate ion releasing ability by incorporating calcium silicate hydrate (2014)
  • Author(s): Hirotaka Maeda, Toshihiro Kasuga
  • Journal Title: Journal of the Ceramic Society of Japan Volume: 122 Issue: 1428 Pages: 591-595
  • DOI: 10.2109/jcersj2.122.591
  • NAID: 130004950984
  • ISSN: 1348-6535, 1882-0743
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] トバモライトへのリン酸塩クラスター導入による高機能化 (2015)
  • Author(s): 前田浩孝、加藤且也、春日敏宏
  • Organizer: 日本セラミックス協会2015年年会
  • Place of Presentation: 岡山大学
  • Year and Date: 2015-03-18 – 2015-03-20
• [Presentation] マグネシウムイオンドープ型トバモライトのタンパク質吸着評価 (2015)
  • Author(s): 石川貴之、前田浩孝、加藤且也、春日敏宏
  • Organizer: 日本セラミックス協会2015年年会
  • Place of Presentation: 岡山大学
  • Year and Date: 2015-03-18 – 2015-03-20
• [Presentation] ケイ酸カルシウム系材料の高機能化を指向した電子状態のチューニング (2014)
  • Author(s): 前田浩孝
  • Organizer: 平成26年度日本セラミックス協会東海支部学術研究発表会
  • Place of Presentation: 名古屋工業大学
  • Year and Date: 2014-12-06
  • Invited
• [Presentation] 生体材料への応用を目指したトバモライトへのリン酸塩クラスターの導入 (2014)
  • Author(s): 前田浩孝、田村友幸、春日敏宏
  • Organizer: 日本無機リン化学会第24回無機リン化学討論会
  • Place of Presentation: 公立学校共済組合高知宿泊所 高知会館
  • Year and Date: 2014-09-25 – 2014-09-26
• [Presentation] ケイ酸カルシウム系材料の環境調和機能化に関する研究 (2014)
  • Author(s): 前田浩孝
  • Organizer: 日本セラミックス協会2014年年会
  • Place of Presentation: 慶應義塾大学日吉キャンパス
• [Presentation] Incorporation of calcium phosphate cluster into calcium silicate hydrate for bone regeneration (2013)
  • Author(s): H. Maeda, T. Tamura, T. Kasuga
  • Organizer: 2013 Composites at Lake Louise
  • Place of Presentation: Alberta, Canada
  • Invited