Development of vascular-like network for creating three-dimensional tissues
| Project/Area Number |
25820383
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Properties in chemical engineering process/Transfer operation/Unit operation
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| Research Institution | Kagoshima University |
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Principal Investigator |
TAKEI Takayuki 鹿児島大学, 理工学研究科, 准教授 (90468059)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 血管 / 再生医療 / 三次元組織 / 血管網 / ファイバー / 毛細血管 |
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| Outline of Final Research Achievements |
We fabricated an engineered vascular-like network comprised assembled hollow alginate hydrogel microfibers. The distance between each flow microchannel (hollow core portions of the microfibers) were set to approximately 100 μm by using microfibers with a gel thickness of approximately 50 μm. Human hepatoblastoma cell line proliferated in the gel portions of the microfibers and maintained their specific function during perfusion culture for 7 days. These results showed that the novel vascular-like networks fabricated here have the potential to allow the creation of volumetric tissues in vitro.
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Report
(3 results)
Research Products
(16 results)
