| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Outline of Final Research Achievements |
We have succeeded in create functional artificial Wnt3a receptors to promote myocardial differentiation from ES cells using antibody-antigen reactions. When the cells expressing the artificial receptors had been stimulated with the cognate ligand, gene expression profiles of them were changed almost the same as the cells stimulated with Wnt3a. Thus, as the artificial Wnt receptors could mimic Wnt signaling in the absence of Wnt3a, this artificial receptor system could serve as a powerful tool to analyze Wnt signaling pathways.
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