Expansion of the central carbon metabolism in Saccharomyces cerevisiae
| Project/Area Number |
25820400
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Osaka University |
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Principal Investigator |
MATSUDA Fumio 大阪大学, 情報科学研究科, 准教授 (50462734)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHII Jun (40512546)
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| Research Collaborator |
MORITA Keisuke
NOMURA Yuta
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | バイオプロダクション / 出芽酵母 / 代謝シミュレーション / 中心代謝経路 / バイオ生産プロセス / 代謝工学 / 酵母 / 中心代謝 / Entner-doudoroff経路 |
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| Outline of Final Research Achievements |
The central carbon metabolism in baker's yeast, Saccharomyces cerevisiae, was expanded by introducing metabolic pathways of other microorganisms to improve a capability of the yeast metabolism for more efficient bioproduction of useful chemicals. The metabolically engineered S. cerevisiae strains expressing bacterial Entner-Doudrouf and phosphoenolpyruvate carboxylase pathways were constructed whose functions were confirmed by the labeling experiment and isobutanol fermentaion test.
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Report
(3 results)
Research Products
(14 results)
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[Presentation] 酵母中心代謝物質の絶対定量2014
Author(s)
西野 駿佑, 岡橋 伸幸, 木下 翔平, 松田 史生, 清水 浩
Organizer
第66回日本生物工学会大会
Place of Presentation
札幌
Year and Date
2014-09-12
Related Report
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