| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
In this study, we describe an understanding of the possible mechanisms that control hiPSC self-renewal in cell culture conditions in the presence of feeder cells. From the standpoint of the deviation from the undifferentiated state in colonies of hiPSCs on feeder layers, the most important aspects for cell migration and growth inside a single colony are a balance between cell-cell and cell-substrate interactions that induces spatial differences in their morphological and functional characteristics. This approach can be applied to an important generic technology for expanding the in the undifferentiated state of hiPSCs.
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