Development of a novel drug delivery system using temperature-responsive DNA aptamer
| Project/Area Number |
25820404
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | The University of Tokushima |
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Principal Investigator |
FURUKAWA Kazuhiro 徳島大学, ヘルスバイオサイエンス研究部, 助教 (00644999)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | SELEX / 4’-チオDNA / DDS / アプタマー / 4'-チオDNA |
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| Outline of Final Research Achievements |
In this study, I aim at a development of novel drug delivery system using DNA. I used 4’-thio DNA instead of natural DNA to increase the biological stability. I carried out an optimization of enzymatic synthesis of 4’-thio DNA and fundamental study of SELEX to obtain 4’-thio DNA aptamer.
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Report
(3 results)
Research Products
(1 results)
