Development of a novel drug delivery system using temperature-responsive DNA aptamer

Research Project

Project/Area Number	25820404
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Biofunction/Bioprocess
Research Institution	The University of Tokushima
Principal Investigator	FURUKAWA Kazuhiro 徳島大学, ヘルスバイオサイエンス研究部, 助教 (00644999)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	SELEX / 4’-チオDNA / DDS / アプタマー / 4'-チオDNA
Outline of Final Research Achievements	In this study, I aim at a development of novel drug delivery system using DNA. I used 4’-thio DNA instead of natural DNA to increase the biological stability. I carried out an optimization of enzymatic synthesis of 4’-thio DNA and fundamental study of SELEX to obtain 4’-thio DNA aptamer.

Report

(3 results)