| Project/Area Number |
25830005
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | University of Toyama |
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Principal Investigator |
Inoue Ran 富山大学, 大学院医学薬学研究部(医学), 助教 (70401817)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 扁桃体 / 恐怖記憶 / ストレス / グルココルチコイド受容体 / 扁桃体外側核 |
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| Outline of Final Research Achievements |
Glucocorticoid receptor (GR) is critical for signaling mediated by stress-induced levels of glucocorticoids. The action of GR on emotional memory varies depending on its distribution in specific brain regions. However, the region-specific role of GR in the lateral nucleus of the amygdala (LA) in fear learning and memory remains unclear. By using a genetic approach and the paradigm of Pavlovian fear conditioning, we found that disruption of LAGR resulted in an auditory-cued fear memory deficit only when the conditioning was strengthened. In response to a single restraint stress (RS) prior to fear conditioning, both control and LAGR knockout (KO) mice exhibited enhancement in contextual fear memory. In contrast, a suppressive effect of prior RS on auditory-cued fear memory, observed in control mice 1 h before conditioning, was attenuated in LAGRKO mice. These findings suggest that LAGR plays differential roles in different stress-modulated patterns of auditory-cued fear memory.
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