A role for ADP Ribosylation Factor 6 signaling in synaptic plasticity and motor laerning

• Project/Area Number: 25830017
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurophysiology / General neuroscience
• Research Institution: Osaka University
• Principal Investigator: HOSHIKO Maki 大阪大学, 生命機能研究科, 招聘研究員 (90645483)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: シナプス / 小脳 / 生理学 / 低分子量Gタンパク質

Outline of Final Research Achievements

We examined a role for ARF6 in the synaptic plasticity and motor learning in the cerebellum. We found that ARF6 is involved in the synaptic plasticity in the cerebellum and controls the morphology of Purkinje cells. In addition, PIP5K is not involved in the ARF6 molecular pathway. Finally, we established the cerebellar culture systems for examining the effect of a candidate molecule.