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Analysis of proteins expressed in the circumventricular organs

Research Project

Project/Area Number 25830021
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurophysiology / General neuroscience
Research InstitutionNational Institute for Basic Biology

Principal Investigator

MATSUMOTO Masahito  基礎生物学研究所, 統合神経生物学研究部門, 研究員 (30625728)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords脳室周囲器官 / 脳弓下器官 / ナトリウムチャンネル / 体液センサー / 体液恒常性
Outline of Final Research Achievements

In animals, osmolality and sodium concentration in body fluids are continuously monitored in the circumventricular organs (CVOs) to keep it. In this study, to figure out the mechanism for the body-fluid homeostasis, we identified the proteins that specifically expressed in CVOs by transcriptome analysis. We also analyzed the expression pattern of Nax, which is known to express in CVOs, in mouse brain. We herein verified that Nax was expressed in neurons in the lateral amygdala of mice, and the interaction between Nax and PSD95 may be involved in promoting the surface expression of Nax channels in neurons.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Endothelin-3 expression in the subfornical organ enhances the sensitivity of Nax, the brain sodium-level sensor, to suppress salt intake2013

    • Author(s)
      Hiyama TY 他
    • Journal Title

      Cell Metab

      Volume: 17 Issue: 4 Pages: 507-519

    • DOI

      10.1016/j.cmet.2013.02.018

    • Related Report
      2013 Research-status Report
    • Peer Reviewed

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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