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PET study on the association between brain sex steroid system and human emotion

Research Project

Project/Area Number 25830024
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurophysiology / General neuroscience
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Takahashi Kayo  国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 上級研究員 (90462697)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsPET / ヒト / aromatase / 気質 / 性ホルモン / estrogen / human / brain / aggression / cooperativeness
Outline of Final Research Achievements

Studies on the association between human personality and sex hormones in the brain have not been performed so much, and little is known about the association. We have developed a novel PET probe, 11C-cetrozole, to observe brain aromatase, an enzyme converting androgen to estrogen. Clinical PET study was performed and showed sex difference and indifference in the association between brain aromatase level and personality. Females might have the association between the amygdala and hypothalamus and aggression etc., and males might have the association between the cortices and harm avoidance etc. The thalamus was the common region which might have the association with cooperativeness in both females and males.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (11 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (4 results) Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Int'l Joint Research] ウプサラ大学(スウェーデン)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] ウィスコンシン大学マディソン校(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Uppsala University(Sweden)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] University of Wisconsin-Madison(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] [11C]Cetrozole: an improved C-[11C]methylated PET probe for aromatase imaging in the brain.2014

    • Author(s)
      Kayo Takahashi, Takamitsu Hosoya, Kayo Onoe, Hisashi, Doi, Hiroko Nagata, Toshiyuki Hiramatsu, Xiao-Le Li, Yumiko Watanabe, Yasuhiro Wada, Tadayuki Takashima, Masaaki Suzuki, Hirotaka Onoe, Yasuyoshi, Watanabe
    • Journal Title

      J. Nucl. Med.

      Volume: 55 Issue: 5 Pages: 852-857

    • DOI

      10.2967/jnumed.113.131474

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Sex difference and indifference in brain aromatase expression by clinical PET study2016

    • Author(s)
      Kayo Takahashi
    • Organizer
      2016 Northeastern Asian Conference on Molecular Imaging-based Precision Medicine
    • Place of Presentation
      Eastern Cloud Hotel, Hanzhou, China
    • Year and Date
      2016-11-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The association between brain aromatase and personality traits.2015

    • Author(s)
      Takahashi K, Hosoya T, Tanaka M, Ishii A, Nakatomi Y, Takahashi K, Wada Y, Watanabe Y
    • Organizer
      8th International Meeting Steroids and Nervous System
    • Place of Presentation
      Hospital San Luigi Gonzaga, Turin, Italy
    • Year and Date
      2015-02-14 – 2015-02-18
    • Related Report
      2014 Research-status Report
  • [Presentation] PET imaging of aromatase expression in human brain and its associate with characters and traits.2014

    • Author(s)
      Takahashi K, Hosoya T, Takashima T, Tanaka M, Ishii A, Nakatomi Y, Tazawa S, Takahashi K, Shiomi S, Wada Y, Watanabe Y
    • Organizer
      World Molecular Imaging Congress 2014
    • Place of Presentation
      COEX convention center, Seoul, South Korea
    • Year and Date
      2014-09-17 – 2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Sex differences between brain aromatase expression and personality traits. -A human PET study.2014

    • Author(s)
      Takahashi K, Hosoya T, Tanaka M, Ishii A, Nakatomi Y, Takahashi K, Wada Y, Watanabe Y.
    • Organizer
      44th Annual conference of International Society of Psychoneuroendocrinology
    • Place of Presentation
      Fairmont The Queen Elizabeth, Montreal, Canada
    • Year and Date
      2014-08-19 – 2014-08-22
    • Related Report
      2014 Research-status Report
  • [Presentation] Brain aromatase and character: Human PET study2013

    • Author(s)
      Takahashi K
    • Organizer
      The 2nd International Conference of Molecular Imaging in Montevideo: A Multitracer and Multidisciplinary Approach
    • Place of Presentation
      Montevideo, Uruguay
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 新しいPETプローブ(11C-セトロゾール)を用いた難治性てんかんの病態解明へのアプローチ2013

    • Author(s)
      露口尚弘、高橋佳代、和田康弘、渡辺恭良
    • Organizer
      第47回日本てんかん学会学術集会
    • Place of Presentation
      福岡県、北九州国際会議場
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2022-02-16  

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