PET study on the association between brain sex steroid system and human emotion
| Project/Area Number |
25830024
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Takahashi Kayo 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 上級研究員 (90462697)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | PET / ヒト / aromatase / 気質 / 性ホルモン / estrogen / human / brain / aggression / cooperativeness |
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| Outline of Final Research Achievements |
Studies on the association between human personality and sex hormones in the brain have not been performed so much, and little is known about the association. We have developed a novel PET probe, 11C-cetrozole, to observe brain aromatase, an enzyme converting androgen to estrogen. Clinical PET study was performed and showed sex difference and indifference in the association between brain aromatase level and personality. Females might have the association between the amygdala and hypothalamus and aggression etc., and males might have the association between the cortices and harm avoidance etc. The thalamus was the common region which might have the association with cooperativeness in both females and males.
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Report
(5 results)
Research Products
(11 results)
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[Journal Article] [11C]Cetrozole: an improved C-[11C]methylated PET probe for aromatase imaging in the brain.2014
Author(s)
Kayo Takahashi, Takamitsu Hosoya, Kayo Onoe, Hisashi, Doi, Hiroko Nagata, Toshiyuki Hiramatsu, Xiao-Le Li, Yumiko Watanabe, Yasuhiro Wada, Tadayuki Takashima, Masaaki Suzuki, Hirotaka Onoe, Yasuyoshi, Watanabe
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Journal Title
J. Nucl. Med.
Volume: 55
Issue: 5
Pages: 852-857
DOI
Related Report
Peer Reviewed
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[Presentation] PET imaging of aromatase expression in human brain and its associate with characters and traits.2014
Author(s)
Takahashi K, Hosoya T, Takashima T, Tanaka M, Ishii A, Nakatomi Y, Tazawa S, Takahashi K, Shiomi S, Wada Y, Watanabe Y
Organizer
World Molecular Imaging Congress 2014
Place of Presentation
COEX convention center, Seoul, South Korea
Year and Date
2014-09-17 – 2014-09-20
Related Report
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