Analysis of prion prpagation using optical tweezers
Project/Area Number |
25830025
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurophysiology / General neuroscience
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Research Institution | Institute of Physical and Chemical Research |
Principal Investigator |
Komi Yusuke 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (20565999)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 光ピンセット / タンパク質一分子 / 天然変性タンパク質 |
Outline of Final Research Achievements |
I investigated the conformational space of a yeast prion protein Sup35NM using optical tweezers.Sup35NM S17R mutant had a part of common structure, but to different confomational space from Sup35NM wild type. Sup35NM S17R with EPEE mutant had similar confomational space to Sup35NM wild type.
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Report
(4 results)
Research Products
(3 results)