Functional morphology of dopamine synapses in the mouse striatum
| Project/Area Number |
25830031
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ドーパミン / 線条体 / ニューロリギン / シナプス |
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| Outline of Final Research Achievements |
Midbrain dopaminergic neurons form a number of so-called dopamine synapses on stratal neurons, and have a strong influence on motor and cognitive functions. However, the molecular composition of dopamine synapses remains elusive. Here we found that dopamine synapses were heterologous contacts between a dopaminergic presynapse and GABAergic postsynapse in the mouse striatum, and synaptic adhesion molecule neuroligin-2 was involved in their formation. These suggest that dopamine synapses can increase the potency and selectivity of dopaminergic modulation by the anchorage of dopamine release sites to target stratal neurons.
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Report
(3 results)
Research Products
(12 results)
